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Literature summary for 3.2.1.166 extracted from

  • Goldshmidt, O.; Zcharia, E.; Aingorn, H.; Guatta-Rangini, Z.; Atzmon, R.; Michal, I.; Pecker, I.; Mitrani, E.; Vlodavsky, I.
    Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequence (2001), J. Biol. Chem., 276, 29178-29187.
    View publication on PubMed
Search for more literature for 3.2.1.166

Cloned(Commentary)

Cloned (Comment) Organism
-
 Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
heparin
-
 Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface the signal peptide sequence accounts for the chicken heparanase being readily secreted and localized in close proximity to the cell surface Gallus gallus 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heparan sulfate proteoglycan + H2O Gallus gallus the heparanase enzyme may play a role in cell migration occurring both at the very early stages of embryogenesis and later on in morphogenesis of the cardiovascular and nervous systems heparan sulfate fragment + truncated heparan sulfate proteoglycan
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 4 potential N-glycosylation sites Gallus gallus
proteolytic modification the full-length chicken heparanase cDNA encodes a 60000 Da proenzyme that is processed at the N-terminus into a 45000 Da highly active enzyme. The signal peptide sequence accounts for the chicken heparanase being readily secreted and localized in close proximity to the cell surface Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
embryo both the chicken heparanase mRNA and protein are expressed 12 h post fertilization, in cells migrating from the epiblast and forming the hypoblast layer. Later on 72 h, the enzyme is preferentially expressed in cells of the developing vascular and nervous systems Gallus gallus
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kidney
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparan sulfate proteoglycan + H2O
-
 Gallus gallus heparan sulfate fragment + truncated heparan sulfate proteoglycan
-
 ?
heparan sulfate proteoglycan + H2O the heparanase enzyme may play a role in cell migration occurring both at the very early stages of embryogenesis and later on in morphogenesis of the cardiovascular and nervous systems Gallus gallus heparan sulfate fragment + truncated heparan sulfate proteoglycan
-
 ?