Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | 14 adenocarcinomas, 13 squamous cell carcinomas, 5 large cell carcinomas, and 5 small cell carcinomas. All of the tumor types express heparanase, which is predominantly localized within the cytoplasm and nucleus. Squamous cell carcinomas, large cell carcinomas, and small cell carcinomas have a similar subcellular distribution of heparanase to adenocarcinomas but the distribution is less widespread | Homo sapiens | - |
lung cancer cell | heparanase expression in lung cancer samples to understand lung tumor progression and malignancy, overview. Heparanase expression tends to correlate with tumor node metastasis staging in non-small cell lung carcinoma | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | heparanase is the only known mammalian glycosidase capable of cleaving heparan sulfate chains. The expression of this enzyme is associated with tumor development because of its ability to degrade extracellular matrix and promote cell invasion | Homo sapiens |