Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
8000 | - |
1 * 50000 + 1 * 8000 | Homo sapiens |
50000 | - |
1 * 50000 + 1 * 8000 | Homo sapiens |
57700 | - |
x * 57700, calculated from amino acid sequence | Homo sapiens |
65000 | - |
x * 65000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y251 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
choroid | - |
Homo sapiens | - |
corneal epithelium | - |
Homo sapiens | - |
lacrimal gland | - |
Homo sapiens | - |
lens | - |
Homo sapiens | - |
retinal pigment epithelium | - |
Homo sapiens | - |
saliva | - |
Homo sapiens | - |
tear | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heparansulfate proteoglycan + H2O | - |
Homo sapiens | ? | - |
? | |
insulin-like growth factor 2 receptor + H2O | - |
Homo sapiens | ? | - |
? | |
low density receptor-related protein-1 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme specifically cleaves the glycol-bond between D-glucuronic acid and N-sulfo glucosamine units leaving 4000-5000 Da stubs attached to the core protein | Homo sapiens | ? | - |
? | |
syndecan-1 + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 65000, SDS-PAGE | Homo sapiens |
? | x * 57700, calculated from amino acid sequence | Homo sapiens |
heterodimer | 1 * 50000 + 1 * 8000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
HPSE | - |
Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | calculated from amino acid sequence | - |
9.2 |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | heparanase is upregulated in primary human tumors | up |
General Information | Comment | Organism |
---|---|---|
physiological function | heparanase/MAPK1 signaling up regulates MMP9 and uPAR causing temporary loss of cell surface syndecan-1. Heparanase also activates AKT, P38, RAC1, PKC, and Src, thereby stimulating syndecan clustering, cell adhesion and tumorigenicity. Chronically elevated heparanase augments heparan sulfate 6-O-sulfation of syndecan-1, increases affinity for FGF1 and 2, and associates with tumor angiogenesis and metastatic potential | Homo sapiens |