Literature summary for 3.2.1.166 extracted from

Levy-Adam, F.; Abboud-Jarrous, G.; Guerrini, M.; Beccati, D.; Vlodavsky, I.; Ilan, N.
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase (2005), J. Biol. Chem., 280, 20457-20466.

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Protein Variants

Protein Variants	Comment	Organism
additional information	deletion mutants lacking heparin binding domains (Lys158-Asn162 or Gln270-Lys280) exhibit no enzymatic activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Lys-Lys-Asp-Cys	0.025 mM or above	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y251	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heparan sulfate proteoglycan + H2O	-	Homo sapiens	heparan sulfate fragment + truncated heparan sulfate proteoglycan	-	?

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Release 2023.1 (January 2023)