Any feedback?
Information on EC 3.1.1.2 - arylesterase
for references in articles please use BRENDA:EC3.1.1.2Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.1.1.2 arylesteraseIUBMB Comments
Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases [7,8]. The natural substrates of the paraoxonases are lactones [7,8], with (+/-)-5-hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate .
Specify your search results
Word Map
- 3.1.1.2
- lipoprotein
- cholesterol
-
high-density
- atherosclerosis
- cardiovascular
-
low-density
- coronary
-
apolipoproteins
- artery
- triglyceride
-
organophosphate
- malondialdehyde
-
hdl-associated
- lactonase
-
anti-oxidant
-
atherogenic
- mellitus
-
c-reactive
-
organophosphorus
-
pesticide
- acetylcholinesterase
- phenylacetate
-
lipoprotein-associated
-
hdl-cholesterol
- homocysteine
- atherogenesis
- esterases
- cholinesterase
- apoa-i
-
antiatherogenic
-
ox-ldl
- chlorpyrifos
-
atheroprotective
-
oxons
- butyrylcholinesterase
- carboxylesterase
-
lipoprotein-cholesterol
- paf-ah
- lp-pla2
- phosphotriesterase
- parathion
- soman
- analysis
- clopidogrel
-
acetylhydrolase
- drug development
-
allozyme
-
oxidant-antioxidant
- sarin
-
lecithin:cholesterol
- medicine
-
thiolactone
The enzyme appears in viruses and cellular organisms
Synonyms
paraoxonase, arylesterase, paraoxonase 1, paraoxonase-1, paraoxonase1, est-1, est-2, paraoxonase/arylesterase, a-esterase, alpha-esterase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A-esterase
alpha-esterase
AREase
aromatic esterase
-
-
-
-
Aryl-ester hydrolase
-
-
-
-
aryldialkylphosphatase
exhibits multiple enzyme activities including organophosphate esterase, carboxyl esterase, lactonase, and phospholipase A2 activity
arylesterase
ESt-A
Est0881
gox0881
K-45
-
-
-
-
paraoxonase
paraoxonase/arylesterase
PON-aryl
PON1
pyrethroid-resistance-associated esterase
Saci_2140
SacPox
SisLac
Sm23
additional information
A-esterase
-
-
-
-
arylesterase
the enzyme is a serine esterase belonging to the A-esterases and contains a catalytic triad composed of Ser156, Asp251, and His281 in the active site
arylesterase
the enzyme is a serine esterase belonging to the A-esterases and contains a catalytic triad composed of Ser156, Asp251, and His281 in the active site
-
paraoxonase
-
-
-
-
SisLac
the enzyme also shows activity of aryldialkylphosphatase (EC 3.1.8.1) and 1,4-lactonase aryldialkylphosphatase(EC 3.1.1.25)
SisLac
the enzyme also shows activity of aryldialkylphosphatase (EC 3.1.8.1) and 1,4-lactonase aryldialkylphosphatase(EC 3.1.1.25)
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a phenyl acetate + H2O = a phenol + acetate
-
-
-
-
a phenyl acetate + H2O = a phenol + acetate
catalytic triad consists of S94, D222 and H251, the active site is significantly occluded
-
a phenyl acetate + H2O = a phenol + acetate
H115 acts as general base, H134 acts in a proton shuttle mechanismto increase H115s basicity
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
aryl-ester hydrolase
Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases [7,8]. The natural substrates of the paraoxonases are lactones [7,8], with (+/-)-5-hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate [8].
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9032-73-9
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,2,2-trifluoroethyl acetate + H2O
2,2,2-trifluoroethanol + acetate
-
-
-
?
4-(chloromethyl)phenyl acetate + H2O
4-chloromethyl phenol + acetate
-
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + caprate
-
-
-
?
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
?
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
?
9-(2,4-dimethylphenoxycarbonyl)-10-methylacridinium triflate + H2O
2,4-dimethylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-chlorophenoxycarbonyl)-10-methylacridinium triflate + H2O
4-chlorophenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate + H2O
9-carboxy-10-methylacridinium triflate + 4-chlorophenol
-
-
-
-
?
9-(4-methylphenoxycarbonyl)-10-methylacridinium triflate + H2O
4-methylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-tert-butylphenoxycarbonyl)-10-methylacridinium triflate + H2O
4-tert-butylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(phenyloxycarbonyl)-10-methylacridinium triflate + H2O
phenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
methyl 4-(acetyloxy)benzoate + H2O
methyl 4-hydroxybenzoate + acetate
-
-
-
?
S-(4-carboxyphenyl)-thioacetate + H2O
4-carboxythiophenol + acetate
-
-
-
?
[(3-[(3-hydroxypropoxy)carbonyl]-5-[[3-([4-[(3-hydroxypropoxy)carbonyl]benzoyl]oxy)propoxy]carbonyl]phenyl)-lambda4-sulfanetriyl]tris(oxidanide) + H2O
terephthalic acid + 5-sulfoisophthalic acid + 1,3-propanediol
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
0.1% of the activity with phenyl acetate, A-type enzyme. 0.25% of the activity with phenyl acetate, B-type enzyme
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
0.1% of the activity with phenyl acetate
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
15.4% activity compared to 4-nitrophenyl acetate
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
5.5% of the activity with phenyl acetate, A-type enzyme. 7% of the activity with phenyl acetate, B-type enzyme
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
13.5% of the activity with phenyl acetate
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
2.1% of the activity with phenyl acetate, A-type enzyme. 2% of the activity with phenyl acetate, B-type enzyme
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
29% of the activity with phenyl acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
2.5% of the activity with phenyl acetate, A-type enzyme. 3.5% of the activity with phenyl acetate, B-type enzyme
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is 2.6fold higher than that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is about 40% of the activity with PON3 (Q15166 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is about 5% of that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
31% of the activity with phenyl acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?