Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dilauroyl phosphatidylcholine | stimulates activity of enzyme variants Q192 and R192 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C284A | mutant with 44fold reduced paraoxonase activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activity is strongly reduced when Ca2+ is removed from the purified enzyme and replaced by Zn2+ | Homo sapiens | |
Zn2+ | activity is strongly reduced when Ca2+ is removed from the purified enzyme and replaced by Zn2+ | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.27 | - |
phenyl acetate | enzyme variant R192 | Homo sapiens | |
0.7 | - |
phenyl acetate | enzyme variant Q192 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required for activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | variant Q192 and R192 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phenyl acetate + H2O | enzyme protein also shows activities of EC 3.1.8.1 and EC 3.1.1.25 | Homo sapiens | phenol + acetate | - |
? |