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Literature summary for 3.1.1.2 extracted from
- Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities (1991), Drug Metab. Dispos., 19, 100-106.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | competitive inhibition | Homo sapiens |  |
| EDTA | - |
Homo sapiens | |
| paraoxon | mixed type inhibition | Homo sapiens | |
| phenyl acetate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.265 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype B blood plasma | Homo sapiens | |
| 0.688 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype A blood plasma | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
x * 43000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme has up to three sugar chains per molecule, and carbohydrate represents 15.8% of the total weight | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood serum | of A and B phenotypes. Human serum contains a single enzyme with both paraoxonase and arylesterase activities | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 558 | - |
purified enzyme from phenotype A blood plasma | Homo sapiens |
| 882 | - |
purified enzyme from phenotype A blood plasma | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arylesterase | - |
Homo sapiens |
| paraoxonase/arylesterase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.401 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype B blood plasma | Homo sapiens | |
| 0.508 | - |
diisopropylfluorophosphate | pH 8.0, 25°C, enzyme from phenotype B blood plasma | Homo sapiens | |
| 0.598 | - |
diisopropylfluorophosphate | pH 8.0, 25°C, enzyme from phenotype A blood plasma | Homo sapiens | |
| 0.885 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype A blood plasma | Homo sapiens | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | - |
- |
5.1 |
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