Reference on EC 2.8.2.8 - [heparan sulfate]-glucosamine N-sulfotransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cheung, W.F.; Eriksson, I.; Kusche-Gulberg, M.; Lindahl, U.; Kjellen, L.
Expression of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase in human kidney 293 cells results in increased N-sulfation of heparan sulfate
Biochemistry
35
5250-5256
1996
Mus musculus
Suzuki, S.; Trenn, R.H.; Strominger, J.L.
Separation of specific mucopolysaccharide sulfotransferases
Biochim. Biophys. Acta
50
169-170
1961
Gallus gallus
-
Hiroshi, M.; Isemura, M.; Yosizawa, Z.
Effects of female hormones on the activity of 3-phosphoadenylylsulphate: desulphated heparan sulphate sulphotransferase in the endometrium of rabbit uterus
Int. J. Biochem.
17
1077-1083
1985
Oryctolagus cuniculus
Ghler, D.; Niemann, R.; Buddecke, E.
Purification and characterization of 3-phosphoadenylylsulfate: N-desulfoheparan sulfate sulfotransferase from arterial tissue
Eur. J. Biochem.
138
301-308
1984
Bos taurus
Wei, Z.; Swiedler, S.J.; Ishihara, M.; Orellana, A.; Hirschberg, C.B.
A single protein catalyzes both N-deacetylation and N-sulfation during the biosynthesis of heparan sulfate
Proc. Natl. Acad. Sci. USA
90
3885-3888
1993
Rattus norvegicus
Hashimoto, Y.; Orellana, A.; Gil, G.; Hirschberg, C.B.
Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase
J. Biol. Chem.
267
15744-15750
1992
Rattus norvegicus
Mandon, E.; Kempner, E.S.; Ishihara, M.; Hirschberg, C.B.
A monomeric protein in the Golgi membrane catalyzes both N-deacetylation and N-sulfation of heparan sulfate
J. Biol. Chem.
269
11729-11733
1994
Rattus norvegicus
Brandan, E.; Hirschberg, C.B.
Purification of rat liver N-heparan-sulfate sulfotransferase
J. Biol. Chem.
263
2417-2422
1988
Rattus norvegicus
Orellana, A.; Hirschberg, C.B.; Wei, Z.; Swiedler, S.J.; Ishihara, M.
Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line
J. Biol. Chem.
269
2270-2276
1994
Mus musculus
Johnson, A.H.; Baker, J.R.
The enzymatic sulphation of heparan sulphate by hens uterus
Biochim. Biophys. Acta
320
341-351
1973
Gallus gallus
Eisenman, R.A.; Balasubramanian, A.S.; Marx, W.
3-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction
Arch. Biochem. Biophys.
119
387-397
1967
Mus musculus
Jansson, L.; Hk, M.; Wasteson, A.; Lindahl, U.
Biosynthesis of heparin. Solubilization and partial characterization of N- and O-sulphotransferases
Biochem. J.
149
49-55
1975
Mus musculus
Foley, T.; Baker, J.R.
A heparan sulphate sulphotransferase from ox lung
Biochem. J.
124
25P-26P
1971
Bos taurus
Sueyoshi, T.; Kakuta, Y.; Pedersen, L.C.; Wall, F.E.; Pedersen, L.G.; Negishi, M.
A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase
FEBS Lett.
433
211-214
1998
Homo sapiens
Toma, L.; Berninsone, P.; Hirschberg, C.B.
The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cells
J. Biol. Chem.
273
22458-22465
1998
Bos taurus (O97583), Bos taurus
Kusche-Gullberg, M.; Eriksson, I.; Pikas, D.S.; Kjellen, L.
Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes
J. Biol. Chem.
273
11902-11907
1998
Rattus norvegicus, Mus musculus (Q3UHN9), Mus musculus
Kakuta, Y.; Sueyoshi, T.; Negishi, M.; Pedersen, L.C.
Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/N-sulfotransferase 1
J. Biol. Chem.
274
10673-10676
1999
Homo sapiens
Aikawa, J.; Esko, J.D.
Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/N-sulfotransferase family
J. Biol. Chem.
274
2690-2695
1999
Cricetulus griseus, Homo sapiens (O95803), Homo sapiens
Gorokhov, A.; Perera, L.; Darden, T.A.; Negishi, M.; Pedersen, L.C.; Pedersen, L.G.
Heparan sulfate biosynthesis: a theoretical study of the initial sulfation step by N-deacetylase/N-sulfotransferase
Biophys. J.
79
2909-2917
2000
Homo sapiens
Aikawa, J.; Grobe, K.; Tsujimoto, M.; Esko, J.D.
Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4
J. Biol. Chem.
276
5876-5882
2001
Homo sapiens (O95803), Homo sapiens (Q9H3R1), Homo sapiens, Mus musculus (P52850), Mus musculus (Q3UHN9), Mus musculus (Q9EQH7), Mus musculus (Q9EQW8), Mus musculus
Grobe, K.; Ledin, J.; Ringvall, M.; Holmborn, K.; Forsberg, E.; Esko, J.D.; Kjellen, L.
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
Biochim. Biophys. Acta
1573
209-215
2002
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Homo sapiens (O95803), Homo sapiens (Q9H3R1), Mus musculus, Mus musculus (Q9EQW8), vertebrata
Duncan, M.B.; Liu, M.; Fox, C.; Liu, J.
Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2
Biochem. Biophys. Res. Commun.
339
1232-1237
2006
Homo sapiens
Grobe, K.; Inatani, M.; Pallerla, S.R.; Castagnola, J.; Yamaguchi, Y.; Esko, J.D.
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
Development
132
3777-3786
2005
Mus musculus
Williams, K.J.; Liu, M.L.; Zhu, Y.; Xu, X.; Davidson, W.R.; McCue, P.; Sharma, K.
Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II
Diabetes
54
1116-1122
2005
Rattus norvegicus
Saribas, A.S.; Mobasseri, A.; Pristatsky, P.; Chen, X.; Barthelson, R.; Hakes, D.; Wang, J.
Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1)
Glycobiology
14
1217-1228
2004
Rattus norvegicus
Yabe, T.; Hata, T.; He, J.; Maeda, N.
Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain
Glycobiology
15
982-993
2005
Mus musculus
Bishop, J.R.; Crawford, B.E.; Esko, J.D.
Cell surface heparan sulfate promotes replication of Toxoplasma gondii
Infect. Immun.
73
5395-5401
2005
Toxoplasma gondii
Nakayama, K.; Natori, Y.; Sato, T.; Kimura, T.; Sugiura, A.; Sato, H.; Saito, T.; Ito, S.
Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis
J. Lab. Clin. Med.
143
106-114
2004
Rattus norvegicus
Pallerla, S.R.; Pan, Y.; Zhang, X.; Esko, J.D.; Grobe, K.
Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development
Dev. Dyn.
236
556-563
2007
Mus musculus
Pan, Y.; Woodbury, A.; Esko, J.D.; Grobe, K.; Zhang, X.
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
Development
133
4933-4944
2006
Mus musculus
Ledin, J.; Ringvall, M.; Thuveson, M.; Eriksson, I.; Wilen, M.; Kusche-Gullberg, M.; Forsberg, E.; Kjellen, L.
Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation
J. Biol. Chem.
281
35727-35734
2006
Mus musculus
Newman, D.R.; Walsh, E.; Apparao, K.B.; Sannes, P.L.
Fibroblast growth factor-binding protein and N-deacetylase/N-sulfotransferase-1 expression in type II cells is modulated by heparin and extracellular matrix
Am. J. Physiol. Lung Cell Mol. Physiol.
293
1314-1320
2007
Rattus norvegicus (Q02353)
Deligny, A.; Denys, A.; Marcant, A.; Melchior, A.; Mazurier, J.; van Kuppevelt, T.H.; Allain, F.
Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases
J. Biol. Chem.
285
1701-1715
2010
Homo sapiens
Duelli, A.; Roennberg, E.; Waern, I.; Ringvall, M.; Kolset, S.O.; Pejler, G.
Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases
J. Immunol.
183
7073-7083
2009
Mus musculus
Jiang, Z.; Michal, J.J.; Wu, X.L.; Pan, Z.; MacNeil, M.D.
The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition
Int. J. Biol. Sci.
7
659-663
2011
Bos taurus
Sheng, J.; Liu, R.; Xu, Y.; Liu, J.
The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate
J. Biol. Chem.
286
19768-19776
2011
Rattus norvegicus
Holley, R.J.; Deligny, A.; Wei, W.; Watson, H.A.; Ninonuevo, M.R.; Dagaelv, A.; Leary, J.A.; Bigger, B.W.; Kjellen, L.; Merry, C.L.
Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking alpha-L-iduronidase
J. Biol. Chem.
286
37515-37524
2011
Mus musculus
Gesteira, T.F.; Coulson-Thomas, V.J.; Taunay-Rodrigues, A.; Oliveira, V.; Thacker, B.E.; Juliano, M.A.; Pasqualini, R.; Arap, W.; Tersariol, I.L.; Nader, H.B.; Esko, J.D.; Pinhal, M.A.
Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1
J. Biol. Chem.
286
5338-5346
2011
Mus musculus
Bush, K.T.; Crawford, B.E.; Garner, O.B.; Nigam, K.B.; Esko, J.D.; Nigam, S.K.
N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland
J. Biol. Chem.
287
42064-42070
2012
Mus musculus
Dou, W.; Xu, Y.; Pagadala, V.; Pedersen, L.C.; Liu, J.
Role of deacetylase activity of N-deacetylase/n-sulfotransferase 1 in forming n-sulfated domain in heparan sulfate
J. Biol. Chem.
290
20427-20437
2015
Homo sapiens (P52848)
Deligny, A.; Dierker, T.; Dagaelv, A.; Lundequist, A.; Eriksson, I.; Nairn, A.V.; Moremen, K.W.; Merry, C.L.; Kjellen, L.
NDST2 (N-deacetylase/N-sulfotransferase-2) enzyme regulates heparan sulfate chain length
J. Biol. Chem.
291
18600-18607
2016
Mus musculus (P52850), Mus musculus
Kero, D.; Bilandzija, T.; Arapovic, L.; Vukojevic, K.; Saraga-Babic, M.
Syndecans and enzymes involved in heparan sulfate biosynthesis and degradation are differentially expressed during human dontogenesis
Front. Physiol.
9
732
2018
Homo sapiens (P52848), Homo sapiens (P52849), Homo sapiens
Ushakov, V.; Tsidulko, A.; De La Bourdonnaye, G.; Kazanskaya, G.; Volkov, A.; Kiselev, R.; Kobozev, V.; Kostromskaya, D.; Gaytan, A.; Krivoshapkin, A.; Aidagulova, S.; Grigorieva, E.
Heparan sulfate biosynthetic system is inhibited in human glioma due to EXT1/2 and HS6ST1/2 down-regulation
Int. J. Mol. Sci.
18
2301
2017
Homo sapiens (P52848), Homo sapiens (P52849)
Li, Y.J.; Yin, F.X.; Zhang, X.K.; Yu, J.; Zheng, S.; Song, X.L.; Wang, F.S.; Sheng, J.Z.
Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates
Biochim. Biophys. Acta
1862
547-556
2018
Homo sapiens (P52848), Homo sapiens (Q9H3R1), Homo sapiens
Zhang, X.; Wang, F.; Sheng, J.
''Coding'' and ''Decoding'' hypothesis for the regulatory mechanism involved in heparan sulfate biosynthesis
Carbohydr. Res.
428
1-7
2016
Homo sapiens (O95803), Homo sapiens (P52848), Homo sapiens (P52849), Homo sapiens (Q9H3R1)
Gesteira, T.F.; Coulson-Thomas, V.J.
Structural basis of oligosaccharide processing by glycosaminoglycan sulfotransferases
Glycobiology
28
885-897
2018
Homo sapiens
Chen, H.; Ambadapadi, S.; Wakefield, D.; Bartee, M.; Yaron, J.R.; Zhang, L.; Archer-Hartmann, S.A.; Azadi, P.; Burgin, M.; Borges, C.; Zheng, D.; Ergle, K.; Muppala, V.; Morshed, S.; Rand, K.; Clapp, W.; Proudfoot, A.; Lucas, A.
Selective deletion of heparan sulfotransferase enzyme, Ndst1, in donor endothelial and myeloid precursor cells significantly decreases acute allograft rejection
Sci. Rep.
8
13433
2018
Mus musculus (Q3UHN9), Mus musculus C57BL/6 (Q3UHN9)
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