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Literature summary for 2.8.2.8 extracted from

  • Williams, K.J.; Liu, M.L.; Zhu, Y.; Xu, X.; Davidson, W.R.; McCue, P.; Sharma, K.
    Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II (2005), Diabetes, 54, 1116-1122.
    View publication on PubMed
Search for more literature for 2.8.2.8

Application

Application Comment Organism
medicine diabetes substantially suppresses hepatic N-deacetylase/N-sulfotransferase-1 mRNA, protein and enzymatic activity. Suppression of hepatic N-deacetylase/N-sulfotransferase-1 may contribute to diabetic dyslipidemia. Stimulation of N-deacetylase/N-sulfotransferase-1 activity by AngII inhibitors may provide cardiovascular protection Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus key enzyme in hepatic heparan sulfate biosynthesis.Diabetes substantially suppresses hepatic N-deacetylase/N-sulfotransferase-1 mRNA, protein and enzymatic activity. Suppression of hepatic N-deacetylase/N-sulfotransferase-1 may contribute to diabetic dyslipidemia. Stimulation of N-deacetylase/N-sulfotransferase-1 activity by AngII inhibitors may provide cardiovascular protection ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
liver diabetes substantially suppresses hepatic N-deacetylase/N-sulfotransferase-1 mRNA, protein and enzymatic activity Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + N-desulfated heparin
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 Rattus norvegicus adenosine 3',5'-bisphosphate + ?
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 ?
additional information key enzyme in hepatic heparan sulfate biosynthesis.Diabetes substantially suppresses hepatic N-deacetylase/N-sulfotransferase-1 mRNA, protein and enzymatic activity. Suppression of hepatic N-deacetylase/N-sulfotransferase-1 may contribute to diabetic dyslipidemia. Stimulation of N-deacetylase/N-sulfotransferase-1 activity by AngII inhibitors may provide cardiovascular protection Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
N-deacetylase/N-sulfotransferase-1
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 Rattus norvegicus
NDST
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 Rattus norvegicus