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Literature summary for 2.8.2.8 extracted from
- Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4 (2001), J. Biol. Chem., 276, 5876-5882.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme NDST1, DNA sequence determination and analysis | Mus musculus |
| isozyme NDST2, DNA sequence determination and analysis | Mus musculus |
| isozyme NDST3, chromosomal localisation | Homo sapiens |
| isozyme NDST3, DNA sequence determination and analysis | Mus musculus |
| isozyme NDST4, DNA sequence determination and analysis | Mus musculus |
| isozyme NDST4, DNA sequence determination and analysis, chromosomal localization | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O95803 | - |
- |
| Homo sapiens | Q9H3R1 | isozyme NDST4 | - |
| Mus musculus | P52850 | isozyme NDST2 | - |
| Mus musculus | Q3UHN9 | isozyme NDST1 | - |
| Mus musculus | Q9EQH7 | isozyme NDST3 | - |
| Mus musculus | Q9EQW8 | isozyme NDST4 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | isozyme distribution in mouse tissues | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activities of isozymes | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + heparosan | - |
Mus musculus | adenosine 3',5'-bisphosphate + heparosan sulfate | - |
? |  |
| 3'-phosphoadenylyl sulfate + heparosan | - |
Homo sapiens | adenosine 3',5'-bisphosphate + heparosan sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine | - |
Mus musculus | adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine | - |
? | |
| 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine | - |
? | |
| 3'-phosphoadenylylsulfate + N-desulfated heparin | - |
Mus musculus | ? | - |
? | |
| 3'-phosphoadenylylsulfate + N-desulfated heparin | - |
Homo sapiens | ? | - |
? | |
| additional information | deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3 | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | molecular modeling of the sulfotransferase domain | Mus musculus |
| More | molecular modeling of the sulfotransferase domain | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GlcNAc N-deacetylase/GlcN N-sulfotransferase | - |
Mus musculus |
| GlcNAc N-deacetylase/GlcN N-sulfotransferase | - |
Homo sapiens |
| NDST | - |
Mus musculus |
| NDST | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Mus musculus |
| 7 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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