Literature summary for 2.8.2.8 extracted from

Ledin, J.; Ringvall, M.; Thuveson, M.; Eriksson, I.; Wilen, M.; Kusche-Gullberg, M.; Forsberg, E.; Kjellen, L.
Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation (2006), J. Biol. Chem., 281, 35727-35734.

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Protein Variants

Protein Variants	Comment	Organism
additional information	construction of NDST1+/- and NDST2-/- mice obtained by crossing NDST2-/- and NDST1 heterozygous mice, genotyping, neither NDST-1-/- nor NDST-2-/- mice display any obvious liver phenotype, deletion of one NDST gene does not influence expression of the other one, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	Mus musculus	in livers of wild-type and NDST mutant mice, overview	adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	mice with mixed genetic backgrounds 129/SvJ/Sv and C57BL/6, genes NDST1 and NDST2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Mus musculus	-
liver	embryonic	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	-	Mus musculus	adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine	product structure analysis, overview	?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	in livers of wild-type and NDST mutant mice, overview	Mus musculus	adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine	-	?

Synonyms

Synonyms	Comment	Organism
N-deacetylase/N-sulfotransferase-2	-	Mus musculus
NDST	-	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Mus musculus

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Release 2023.1 (January 2023)