Literature summary for 2.8.2.8 extracted from

Grobe, K.; Inatani, M.; Pallerla, S.R.; Castagnola, J.; Yamaguchi, Y.; Esko, J.D.
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function (2005), Development, 132, 3777-3786.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	Mus musculus	cerebral hypoplasia and craniofacial defects are detected in mice lacking heparan sulfate Ndst1 gene function. Ndst1 is a crucial regulator of mammalian forebrain and facial development. Properly modified heparan sulfate is necessary for neuronal, glia and neural crest development	adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	cerebral hypoplasia and craniofacial defects are detected in mice lacking heparan sulfate Ndst1 gene function. Ndst1 is a crucial regulator of mammalian forebrain and facial development. Properly modified heparan sulfate is necessary for neuronal, glia and neural crest development	Mus musculus	adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine	-	?

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Release 2023.1 (January 2023)