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Literature summary for 2.8.2.8 extracted from

  • Pallerla, S.R.; Pan, Y.; Zhang, X.; Esko, J.D.; Grobe, K.
    Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development (2007), Dev. Dyn., 236, 556-563.
    View publication on PubMed
Search for more literature for 2.8.2.8

Protein Variants

Protein Variants Comment Organism
additional information construction of mutant mice bearing a targeted disruption of the heparan sulfate-generating enzyme Ndst1, the mutant mice show severe developmental defects of the forebrain and the skull, overview, determination of molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, organ defect phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Mus musculus
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
 ?
additional information Mus musculus heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development, disruption of heparan sulfate synthesis in vertebrate development causes malformations that are composites of those caused by mutations of multiple heparan sulfate binding growth factors and morphogens, overview, molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene Ndst1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Mus musculus adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
 ?
additional information heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development, disruption of heparan sulfate synthesis in vertebrate development causes malformations that are composites of those caused by mutations of multiple heparan sulfate binding growth factors and morphogens, overview, molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
GlcNAc N-deacetylase/GlcN N-sulfotransferase 1
-
 Mus musculus
Ndst1
-
 Mus musculus