Reference on EC 2.7.11.31 - [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase and Organism(s) Rattus norvegicus and UniProt Accession P54645
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ingebritsen, T.S.; Parker, R.A.; Gibson, D.M.
Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system
J. Biol. Chem.
256
1138-1144
1981
Rattus norvegicus
Carling, D.; Clarke, P.R.; Hardie, D.G.
Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase
Methods Enzymol.
200
362-371
1991
Rattus norvegicus, Rattus norvegicus Wistar
Stapleton, D.; Mitchelhill, K.I.; Gao, G.; Widmer, J.; Michell, B.J.; Teh, T.; House, C.M.; Fernandez, C.S.; Cox, T.; Witters, L.A.; Kemp, B.E.
Mammalian AMP-activated protein kinase subfamily
J. Biol. Chem.
271
611-614
1996
Homo sapiens, Rattus norvegicus, Sus scrofa
Beg, Z.H.; Stonik, J.A.; Brewer, H.B.
3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation
Proc. Natl. Acad. Sci. USA
75
3678-3682
1978
Rattus norvegicus
Ingebritsen, T.S.; Lee, H.S.; Parker, R.A.; Gibson, D.M.
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation
Biochem. Biophys. Res. Commun.
81
1268-1277
1978
Rattus norvegicus
Beg, Z.H.; Stonik, J.A.
Reversible inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: reductase kinase and mevalonate kinase are separate enzymes
Biochem. Biophys. Res. Commun.
108
559-566
1982
Rattus norvegicus
Ferrer, A.; Hegardt, F.G.
Phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase
Arch. Biochem. Biophys.
230
227-237
1984
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Harwood, H.J.; Brandt, K.G.; Rodwell, V.W.
Allosteric activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by nucleoside diphosphates
J. Biol. Chem.
259
2810-2815
1984
Rattus norvegicus
Ferrer, A.; Caelles, C.; Massot, N.; Hegardt, F.G.
Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5-monophosphate
Biochem. Biophys. Res. Commun.
132
497-504
1985
Rattus norvegicus
Beg, Z.H.; Stonik, J.A.; Brewer, H.B.
Phosphorylation and modulation of the enzymic activity of native and protease-cleaved purified hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase by a calcium/calmodulin-dependent protein kinase
J. Biol. Chem.
262
13228-13240
1987
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Ferrer, A.; Caelles, C.; Massot, N.; Hegardt, F.G.
Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates
Biol. Chem. Hoppe-Seyler
368
249-257
1987
Rattus norvegicus
Weekes, J.; Ball, K.L.; Caudwell, F.B.; Hardie, D.G.
Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides
FEBS Lett.
334
335-339
1993
Brassica oleracea, Rattus norvegicus
Omkumar, R.V.; Darnay, B.G.; Rodwell, V.W.
Modulation of syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871 [published erratum appears in J Biol Chem 1994 Jun 10;269(23):16518]
J. Biol. Chem.
269
6810-6814
1994
Rattus norvegicus
Henin, N.; Vincent, M.F.; Van den Berghe, G.
Stimulation of rat liver AMP-activated protein kinase by AMP analogues
Biochim. Biophys. Acta
1290
197-203
1996
Rattus norvegicus
Park, H.; Kaushik, V.K.; Constant, S.; Prentki, M.; Przybytkowski, E.; Ruderman, N.B.; Saha, A.K.
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
J. Biol. Chem.
277
32571-32577
2002
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Beg, Z.H.; Stonik, J.A.; Brewer, B.
Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Proc. Natl. Acad. Sci. USA
76
4375-4379
1979
Rattus norvegicus
Weekes, J.; Hawley, S.A.; Corton, J.; Shugar, D.; Hardie, D.G.
Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues
Eur. J. Biochem.
219
751-757
1994
Rattus norvegicus
Beg, Z.H.; Stonik, J.A.; Brewer, B.
In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone
Proc. Natl. Acad. Sci. USA
81
7293-7297
1984
Rattus norvegicus
Hawley, S.A.; Selbert, M.A.; Goldstein, E.G.; Edelman, A.M.; Carling, D.; Hardie, D.G.
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms
J. Biol. Chem.
270
27186-27191
1995
Rattus norvegicus
Hawley, S.A.; Davison, M.; Woods, A.; Davies, S.P.; Beri, R.K.; Carling, D.; Hardie, D.G.
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
J. Biol. Chem.
271
27879-27887
1996
Rattus norvegicus
Woods, A.; Cheung, P.C.; Smith, F.C.; Davison, M.D.; Scott, J.; Beri, R.K.; Carling, D.
Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro
J. Biol. Chem.
271
10282-10290
1996
Rattus norvegicus
Crute, B.E.; Seefeld, K.; Gamble, J.; Kemp, B.E.; Witters, L.A.
Functional domains of the a1 catalytic subunit of the AMP-activated protein kinase
J. Biol. Chem.
273
35347-35354
1998
Rattus norvegicus
Muoio, D.M.; Seefeld, K.; Witters, L.A.; Coleman, R.A.
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
Biochem. J.
338
783-791
1999
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Stein, S.C.; Woods, A.; Jones, N.A.; Davison, M.D.; Carling, D.
The regulation of AMP-activated protein kinase by phosphorylation
Biochem. J.
345
437-443
2000
Rattus norvegicus
-
Musi, N.; Hayashi, T.; Fujii, N.; Hirshman, M.F.; Witters, L.A.; Goodyear, L.J.
AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle
Am. J. Physiol.
280
E677-684
2001
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Woods, A.; Vertommen, D.; Neumann, D.; Tuerk, R.; Bayliss, J.; Schlattner, U.; Wallimann, T.; Carling, D.; Rider, M.H.
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis
J. Biol. Chem.
278
28434-28442
2003
Rattus norvegicus
Samari, H.R.; Moeller, M.T.N.; Holden, L.; Asmyhr, T.; Seglen, P.O.
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophygy-suppressive toxins
Biochem. J.
386
237-244
2005
Rattus norvegicus
Crawford, R.M.; Treharne, K.J.; Best, O.G.; Muimo, R.; Riemen, C.E.; Mehta, A
A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase alpha1 in liver and lung
Biochem. J.
392
201-209
2005
Homo sapiens, Rattus norvegicus
Daval, M.; Diot-Dupuy F.; Bazin, R.; Hainault, I.; Viollet, B.; Vaulont, S.; Hajduch, E.; Ferr, P.; Foufelle, F.
Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
J. Biol. Chem.
280
25250-25257
2005
Mus musculus, Rattus norvegicus
Mukhtar, M.H.; Payne, V.A.; Arden, C.; Harbottle, A.; Khan, S.; Lange, A.J.; Agius, L.
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R766-R774
2008
Rattus norvegicus
Borger, D.R.; Gavrilescu, L.C.; Bucur, M.C.; Ivan, M.; Decaprio, J.A.
AMP-activated protein kinase is essential for survival in chronic hypoxia
Biochem. Biophys. Res. Commun.
370
230-234
2008
Rattus norvegicus
Garcia-Villafranca, J.; Guillen, A.; Castro, J.
Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver
Biochimie
90
460-466
2008
Rattus norvegicus
Kim, S.J.; Jung, J.Y.; Kim, H.W.; Park, T.
Anti-obesity effects of Juniperus chinensis extract are associated with increased AMP-activated protein kinase expression and phosphorylation in the visceral adipose tissue of rats
Biol. Pharm. Bull.
31
1415-1421
2008
Rattus norvegicus
Gybina, A.A.; Prohaska, J.R.
Copper deficiency results in AMP-activated protein kinase activation and acetyl-CoA carboxylase phosphorylation in rat cerebellum
Brain Res.
1204
69-76
2008
Rattus norvegicus
Witczak, C.A.; Sharoff, C.G.; Goodyear, L.J.
AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism
Cell. Mol. Life Sci.
65
3737-3755
2008
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus
McCrimmon, R.J.; Shaw, M.; Fan, X.; Cheng, H.; Ding, Y.; Vella, M.C.; Zhou, L.; McNay, E.C.; Sherwin, R.S.
Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
Diabetes
57
444-450
2008
Rattus norvegicus
Robertson, T.P.; Mustard, K.J.; Lewis, T.H.; Clark, J.H.; Wyatt, C.N.; Blanco, E.A.; Peers, C.; Hardie, D.G.; Evans, A.M.
AMP-activated protein kinase and hypoxic pulmonary vasoconstriction
Eur. J. Pharmacol.
595
39-43
2008
Rattus norvegicus
Christ-Crain, M.; Kola, B.; Lolli, F.; Fekete, C.; Seboek, D.; Wittmann, G.; Feltrin, D.; Igreja, S.C.; Ajodha, S.; Harvey-White, J.; Kunos, G.; Mueller, B.; Pralong, F.; Aubert, G.; Arnaldi, G.; Giacchetti, G.; Boscaro, M.; Grossman, A.B.; Korbonits, M.
AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushings syndrome
FASEB J.
22
1672-1683
2008
Homo sapiens, Rattus norvegicus
Summermatter, S.; Mainieri, D.; Russell, A.P.; Seydoux, J.; Montani, J.P.; Buchala, A.; Solinas, G.; Dulloo, A.G.
Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase
FASEB J.
22
774-785
2008
Rattus norvegicus
Hardie, D.G.
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease
FEBS Lett.
582
81-89
2008
Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Giardia intestinalis, Homo sapiens, Mus musculus, Physcomitrium patens, Rattus norvegicus, Schizosaccharomyces pombe, Trypanosoma brucei
Ronnett, G.V.; Aja, S.
AMP-activated protein kinase in the brain
Int. J. Obes.
32
S42-S48
2008
Rattus norvegicus
Riek, U.; Scholz, R.; Konarev, P.; Rufer, A.; Suter, M.; Nazabal, A.; Ringler, P.; Chami, M.; Mueller, S.A.; Neumann, D.; Forstner, M.; Hennig, M.; Zenobi, R.; Engel, A.; Svergun, D.; Schlattner, U.; Wallimann, T.
Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding
J. Biol. Chem.
283
18331-18343
2008
Rattus norvegicus (P54645), Rattus norvegicus (P80385), Rattus norvegicus (P80386), Rattus norvegicus (Q09137)
Iseli, T.J.; Oakhill, J.S.; Bailey, M.F.; Wee, S.; Walter, M.; van Denderen, B.J.; Castelli, L.A.; Katsis, F.; Witters, L.A.; Stapleton, D.; Macaulay, S.L.; Michell, B.J.; Kemp, B.E.
AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267
J. Biol. Chem.
283
4799-4807
2008
Homo sapiens, Rattus norvegicus
Vadasz, I.; Dada, L.A.; Briva, A.; Trejo, H.E.; Welch, L.C.; Chen, J.; Toth, P.T.; Lecuona, E.; Witters, L.A.; Schumacker, P.T.; Chandel, N.S.; Seeger, W.; Sznajder, J.I.
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis
J. Clin. Invest.
118
752-762
2008
Rattus norvegicus
Hegarty, B.D.; Turner, N.; Cooney, G.J.; Kraegen, E.W.
Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase
Acta Physiol. (Oxf.)
196
129-145
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Oakhill, J.S.; Scott, J.W.; Kemp, B.E.
Structure and function of AMP-activated protein kinase
Acta Physiol. (Oxf.)
196
3-14
2009
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe, Sus scrofa
McBride, A.; Hardie, D.G.
AMP-activated protein kinase--a sensor of glycogen as well as AMP and ATP?
Acta Physiol. (Oxf.)
196
99-113
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Zou, M.H.; Wu, Y.
AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function
Clin. Exp. Pharmacol. Physiol.
35
535-545
2008
Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces sp.
Li, C.; Keaney, J.F.
AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease
Curr. Opin. Pharmacol.
10
111-115
2010
Saccharomyces cerevisiae, Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Kelly, M.; Gauthier, M.S.; Saha, A.K.; Ruderman, N.B.
Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization
Diabetes
58
1953-1960
2009
Rattus norvegicus
Chan, A.Y.; Dolinsky, V.W.; Soltys, C.L.; Viollet, B.; Baksh, S.; Light, P.E.; Dyck, J.R.
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
J. Biol. Chem.
283
24194-24201
2008
Mus musculus, Rattus norvegicus
Meares, G.P.; Hughes, K.J.; Jaimes, K.F.; Salvatori, A.S.; Rhodes, C.J.; Corbett, J.A.
AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death
J. Biol. Chem.
285
3191-3200
2010
Rattus norvegicus
Bendayan, M.; Londono, I.; Kemp, B.E.; Hardie, G.D.; Ruderman, N.; Prentki, M.
Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy
J. Histochem. Cytochem.
57
963-971
2009
Rattus norvegicus
Kola, B.
Role of AMP-activated protein kinase in the control of appetite
J. Neuroendocrinol.
20
942-951
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Chen, L.; Jiao, Z.H.; Zheng, L.S.; Zhang, Y.Y.; Xie, S.T.; Wang, Z.X.; Wu, J.W.
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
Nature
459
1146-1149
2009
Saccharomyces cerevisiae, Rattus norvegicus, Schizosaccharomyces pombe
Spasic, M.R.; Callaerts, P.; Norga, K.K.
AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons
Neuroscientist
15
309-316
2009
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
Mobbs, J.I.; Koay, A.; Di Paolo, A.; Bieri, M.; Petrie, E.J.; Gorman, M.A.; Doughty, L.; Parker, M.W.; Stapleton, D.I.; Griffin, M.D.; Gooley, P.R.
Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase
Biochem. J.
468
245-257
2015
Rattus norvegicus (P80386), Rattus norvegicus (Q9QZH4)
Gao, F.; Qian, Y.J.; Chen, F.H.; Zhu, H.B.
Comparative analysis of stimulation and binding characteristics of adenosine analogs to AMP-activated protein kinase
J. Asian Nat. Prod. Res.
21
916-927
2019
Rattus norvegicus
Moral-Sanz, J.; Mahmoud, A.; Ross, F.; Eldstrom, J.; Fedida, D.; Hardie, D.; Evans, A.
AMP-activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation
J. Physiol.
594
4901-4915
2016
Rattus norvegicus
Hermann, R.; Mestre Cordero, V.; Fernandez Pazos, M.; Reznik, F.; Velez, D.; Savino, E.; Marina Prendes, M.; Varela, A.
Differential effects of AMP-activated protein kinase in isolated rat atria subjected to simulated ischemia-reperfusion depending on the energetic substrates available
Pflugers Arch.
470
367-383
2018
Rattus norvegicus
