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Literature summary for 2.7.11.31 extracted from

  • Spasic, M.R.; Callaerts, P.; Norga, K.K.
    AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons (2009), Neuroscientist, 15, 309-316.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide ribonucleoside AICAR, a potent activator of AMPK. If treated with small to moderate concentrations, embryonic hippocampal neurons cultured in conditions of glucose deprivation have improved survival Rattus norvegicus
5-aminoimidazole-4-carboxamide ribonucleoside AICAR, has a proapoptotic effect in neuroblastoma cells. AICAR does not significantly change AMPK activity after prolonged exposure (48 h), when its apoptotic effect becomes evident Homo sapiens
additional information elevated phosphorylation of AMPK and R2-GABAB in the hippocampus of a rat ischemic in vivo model Rattus norvegicus
additional information mice subjected to moderate diet restriction (60% of the requirement) are characterized by AMPK activation. Drastic diet restriction (40% of the requirement) leads to further elevation in AMPK activity Mus musculus
NO contributes to activation of AMPK in stroke Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information in neurodegeneration model in which apoptotic neurodegeneration of neonatal mouse brains is induced by ethanol, AMPK activity is attenuated Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm AMPKalpha-1 is the primarily cytoplasmic isoform Mus musculus 5737
-
nucleus AMPKalpha-2 is the predominantly neuronal nuclear isoform Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Rattus norvegicus
-
embryo
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
neuroblastoma cell
-
 Homo sapiens
-
neuron in neurons throughout the developing and adult brain Mus musculus
-
neuron in neurons throughout the developing and adult brain Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + actin
-
 Mus musculus ADP + [actin]phosphate
-
 ?
ATP + ATPase
-
 Mus musculus ADP + [ATPase]phosphate
-
 ?
ATP + beta-synuclein
-
 Mus musculus ADP + [beta-synuclein]phosphate
-
 ?
ATP + bis(5'-nucleosyl)-tetraphosphatase
-
 Mus musculus ADP + [bis(5'-nucleosyl)-tetraphosphatase]phosphate
-
 ?
ATP + citrate synthase
-
 Mus musculus ADP + [citrate synthase]phosphate
-
 ?
ATP + collapsing response mediator protein-2
-
 Mus musculus ADP + [collapsing response mediator protein-2]phosphate
-
 ?
ATP + dephospho-beta-tubulin
-
 Rattus norvegicus ADP + [beta-tubulin]phosphate
-
 ?
ATP + dihydropyrimidinase-like 2
-
 Mus musculus ADP + [dihydropyrimidinase-like 2]phosphate
-
 ?
ATP + dynein intermediate chain 2
-
 Mus musculus ADP + [dynein intermediate chain 2]phosphate
-
 ?
ATP + elongation factor Ts
-
 Mus musculus ADP + [elongation factor Ts]phosphate
-
 ?
ATP + elongation factor Tu
-
 Mus musculus ADP + [elongation factor Tu]phosphate
-
 ?
ATP + far upstream element binding protein 1
-
 Mus musculus ADP + [far upstream element binding protein 1]phosphate
-
 ?
ATP + fascin homologue 1
-
 Mus musculus ADP + [fascin homologue 1]phosphate
-
 ?
ATP + glial fibrillary acidic protein
-
 Mus musculus ADP + [glial fibrillary acidic protein]phosphate
-
 ?
ATP + glutamate dehydrogenase 1
-
 Mus musculus ADP + [glutamate dehydrogenase 1]phosphate
-
 ?
ATP + glutamine synthetase
-
 Mus musculus ADP + [glutamine synthetase]phosphate
-
 ?
ATP + glyceraldehyde-3-phosphate dehydrogenase
-
 Mus musculus ADP + [glyceraldehyde-3-phosphate dehydrogenase]phosphate
-
 ?
ATP + heat shock protein 8
-
 Mus musculus ADP + [heat shock protein 8]phosphate
-
 ?
ATP + heterogeneous nuclear ribonucleoproteins A2/B1
-
 Mus musculus ADP + [heterogeneous nuclear ribonucleoproteins A2/B1]phosphate
-
 ?
ATP + neurofilament triplet L protein
-
 Mus musculus ADP + [neurofilament triplet L protein]phosphate
-
 ?
ATP + Ngg1 interacting factor 3-like 1
-
 Mus musculus ADP + [Ngg1 interacting factor 3-like 1]phosphate
-
 ?
ATP + NmrA-like family domain containing 1
-
 Mus musculus ADP + [NmrA-like family domain containing 1]phosphate
-
 ?
ATP + nucleolin
-
 Mus musculus ADP + [nucleolin]phosphate
-
 ?
ATP + protein GFAP
-
 Rattus norvegicus ADP + [protein GFAP]phosphate
-
 ?
ATP + protein kinase C and casein kinase substrate in neurons protein 1
-
 Mus musculus ADP + [protein kinase C and casein kinase substrate in neurons protein 1]phosphate
-
 ?
ATP + protein NF-L
-
 Rattus norvegicus ADP + [protein NF-L]phosphate
-
 ?
ATP + synapsin-1
-
 Mus musculus ADP + [synapsin-1]phosphate
-
 ?
ATP + telomerase-binding protein p23
-
 Mus musculus ADP + [telomerase-binding protein p23]phosphate
-
 ?
ATP + tripeptidyl-peptidase 2
-
 Mus musculus ADP + [tripeptidyl-peptidase 2]phosphate
-
 ?
ATP + tubulin
-
 Mus musculus ADP + [tubulin]phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMP-activated protein kinase
-
 Homo sapiens
AMP-activated protein kinase
-
 Rattus norvegicus
AMP-activated protein kinase
-
 Saccharomyces cerevisiae
AMPK
-
 Mus musculus
AMPK
-
 Homo sapiens
AMPK
-
 Rattus norvegicus
AMPK
-
 Saccharomyces cerevisiae
Snf1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction mice deficient in AMPKalpha-2 have smaller infarct volumes after middle cerebral artery occlusion, whereas AMPKalpha-1 deficiency has no effect compared to wild-type Mus musculus