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Literature summary for 2.7.11.31 extracted from
- AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushings syndrome (2008), FASEB J., 22, 1672-1683.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione | - |
Homo sapiens |  |
| AMP | - |
Homo sapiens | |
| AMP | - |
Rattus norvegicus | |
| glucocorticoid | treatment inhibits AMPK activity in rat adipose tissue and heart, while stimulating it in the liver and hypothalamus, similar to activity in vitro in the primary adipose and hypothalamic cells | Homo sapiens | |
| glucocorticoid | treatment inhibits AMPK activity in rat adipose tissue and heart, while stimulating it in the liver and hypothalamus, similar to activity in vitro in the primary adipose and hypothalamic cells | Rattus norvegicus | |
| metformin | - |
Homo sapiens | |
| metformin | co-administration of dexamethasone and metformin decreases insulin-stimulated glucose uptake compared with metformin alone | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| quantitative AMPK expression analysis in different tissues with or without glucocorticosteroid treatment, overview | Homo sapiens |
| quantitative AMPK expression analysis in different tissues with or without glucocorticosteroid treatment, overview | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dexamethasone | decreases in AMPK activity in treated adipocytes. The inhibitory effect of dexamethasone on AMPK activity is antagonized by co-administration of metformin at 0.01 mM, which increases AMPK activity to 224% compared with dexamethasone treatment alone | Homo sapiens | |
| glucocorticoid | treatment inhibits AMPK activity in rat adipose tissue and heart, while stimulating it in the liver and hypothalamus, similar to activity in vitro in the primary adipose and hypothalamic cells | Homo sapiens | |
| glucocorticoid | treatment inhibits AMPK activity in rat adipose tissue and heart, while stimulating it in the liver and hypothalamus, similar to activity in vitro in the primary adipose and hypothalamic cells | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes representing a mechanism in Cushings syndrome, overview. activation of AMPK stimulates appetite in the hypothalamus and stimulates catabolic processes in the periphery | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
patients with Cushings syndrome | - |
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| adipose tissue | visceral adipose tissue, the predominant AMPK subunit in adipose tissue is AMPKalpha1 | Rattus norvegicus | - |
| cardiac muscle | - |
Homo sapiens | - |
| cardiac muscle | - |
Rattus norvegicus | - |
| cell culture | primary hypothalamic or adipose cells | Homo sapiens | - |
| cell culture | primary hypothalamic or adipose cells | Rattus norvegicus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| hepatoma cell | - |
Homo sapiens | - |
| hypothalamus | - |
Homo sapiens | - |
| hypothalamus | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | AMPK activity in the liver is significantly higher in corticosterone-treated rats compared with the untreated ones | Rattus norvegicus | - |
| skeletal muscle | - |
Homo sapiens | - |
| skeletal muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes representing a mechanism in Cushings syndrome, overview. activation of AMPK stimulates appetite in the hypothalamus and stimulates catabolic processes in the periphery | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenosine monophosphate-activated protein kinase | - |
Homo sapiens |
| adenosine monophosphateactivated protein kinase | - |
Rattus norvegicus |
| AMPK | - |
Homo sapiens |
| AMPK | - |
Rattus norvegicus |
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