Literature summary for 2.7.11.31 extracted from

Moral-Sanz, J.; Mahmoud, A.; Ross, F.; Eldstrom, J.; Fedida, D.; Hardie, D.; Evans, A.
AMP-activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation (2016), J. Physiol., 594, 4901-4915 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
5-aminoimidazole-4-carboxamide riboside	-	Rattus norvegicus
A-769662	-	Rattus norvegicus
[([5-(5-oxo-4,5-dihydro-1,2-oxazol-3-yl)furan-2-yl]phosphoryl)bis(oxy)methylene]bis(2-methylpropanoate)	i.e. C13	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
compound C	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + recombinant human Kv1.5 channel	Rattus norvegicus	-	ADP + phosphorylated recombinant human Kv1.5 channel	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
myocyte	-	Rattus norvegicus	-
pulmonary artery	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + recombinant human Kv1.5 channel	-	Rattus norvegicus	ADP + phosphorylated recombinant human Kv1.5 channel	-	?

Subunits

Subunits	Comment	Organism
heterotrimer	-	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Rattus norvegicus
AMPK	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	the enzyme couples inhibition of mitochondrial metabolism by hypoxia to acute hypoxic pulmonary vasoconstriction and progression of pulmonary hypertension. Inhibition of complex I of the mitochondrial electron transport chain activates the enzyme and inhibits Kv1.5 channels in pulmonary arterial myocytes. The enzyme is the primary mediator of reductions in Kv1.5 channels following inhibition of mitochondrial oxidative phosphorylation during hypoxia and by mitochondrial poisons	Rattus norvegicus

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Release 2023.1 (January 2023)