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Literature summary for 2.7.11.31 extracted from

  • Daval, M.; Diot-Dupuy F.; Bazin, R.; Hainault, I.; Viollet, B.; Vaulont, S.; Hajduch, E.; Ferr้, P.; Foufelle, F.
    Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes (2005), J. Biol. Chem., 280, 25250-25257.
    View publication on PubMed
Search for more literature for 2.7.11.31

Cloned(Commentary)

Cloned (Comment) Organism
expression of a dominant-negative mutant or of a constitutively active mutant of AMPK in adipocytes via adenovirus transfection Mus musculus
expression of a dominant-negative mutant or of a constitutively active mutant of AMPK in adipocytes via adenovirus transfection Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information lipolysis is reduced in mutant with expression of a dominant-negative AMPK of in a null-mutant Mus musculus
additional information lipolysis is reduced in mutant with expression of a dominant-negative AMPK of in a null-mutant Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + hormone-sensitive lipase Mus musculus HSL is a key enzyme in controlling lipolysis in adipocytes, phosphorylation at Ser565 by AMPK reduces its translocation toward lipid droplets ADP + phosphorylated hormone-sensitive lipase
-
 ?
ATP + hormone-sensitive lipase Rattus norvegicus HSL is a key enzyme in controlling lipolysis in adipocytes, phosphorylation at Ser565 by AMPK reduces its translocation toward lipid droplets ADP + phosphorylated hormone-sensitive lipase
-
 ?
additional information Mus musculus mechanism of lipolytic enzyme activity modulation, regulation, overview ?
-
 ?
additional information Rattus norvegicus mechanism of lipolytic enzyme activity modulation, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-
adipocyte primary Mus musculus
-
adipocyte primary Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + hormone-sensitive lipase
-
 Mus musculus ADP + phosphorylated hormone-sensitive lipase
-
 ?
ATP + hormone-sensitive lipase
-
 Rattus norvegicus ADP + phosphorylated hormone-sensitive lipase
-
 ?
ATP + hormone-sensitive lipase HSL is a key enzyme in controlling lipolysis in adipocytes, phosphorylation at Ser565 by AMPK reduces its translocation toward lipid droplets Mus musculus ADP + phosphorylated hormone-sensitive lipase
-
 ?
ATP + hormone-sensitive lipase HSL is a key enzyme in controlling lipolysis in adipocytes, phosphorylation at Ser565 by AMPK reduces its translocation toward lipid droplets Rattus norvegicus ADP + phosphorylated hormone-sensitive lipase
-
 ?
additional information mechanism of lipolytic enzyme activity modulation, regulation, overview Mus musculus ?
-
 ?
additional information mechanism of lipolytic enzyme activity modulation, regulation, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMP-activated protein kinase
-
 Rattus norvegicus
AMPK
-
 Mus musculus
AMPK
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus