Literature summary for 2.7.11.31 extracted from

Hermann, R.; Mestre Cordero, V.; Fernandez Pazos, M.; Reznik, F.; Velez, D.; Savino, E.; Marina Prendes, M.; Varela, A.
Differential effects of AMP-activated protein kinase in isolated rat atria subjected to simulated ischemia-reperfusion depending on the energetic substrates available (2018), Pflugers Arch., 470, 367-383 .

Search for more literature for 2.7.11.31

Inhibitors

Inhibitors	Comment	Organism	Structure
compound C	i.e. 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the enzymes alpha subunit is phosphorylated at Thr172	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
atrium	-	Rattus norvegicus	-
heart	-	Rattus norvegicus	-

Subunits

Subunits	Comment	Organism
heterotrimer	-	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Rattus norvegicus
AMPK	-	Rattus norvegicus
AMPKalpha	isoform	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	enzyme activity significantly increases during ischemia, remaining activated during reperfusion	up

General Information

General Information	Comment	Organism
physiological function	intrinsic activation of the enzyme has functional protective effects in the reperfused atria when glucose is the only available energetic substrate whereas it is deleterious when palmitate is also available	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)