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Literature summary for 2.7.11.31 extracted from

  • Borger, D.R.; Gavrilescu, L.C.; Bucur, M.C.; Ivan, M.; Decaprio, J.A.
    AMP-activated protein kinase is essential for survival in chronic hypoxia (2008), Biochem. Biophys. Res. Commun., 370, 230-234.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant AMPKalpha2 in human BJ fibroblast cells and in 786-0 renal carcinoma cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
D157A AMPKalpha2 mutant, expression of a dominant-negative AMPK alpha results in a decreased ATP level and significantly compromised survival in hypoxia Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR Rattus norvegicus
compound C i.e. dorsomorphin or 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine Rattus norvegicus
additional information prosurvival effects of rapamycin are consistent with mTOR inhibition being a critical downstream mediator of AMPK in persistent low oxygen Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus AMP-activated protein kinase is essential for survival in chronic hypoxia ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AMP-activated protein kinase is essential for survival in chronic hypoxia Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Rattus norvegicus
AMPK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus