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Literature summary for 2.7.11.31 extracted from

  • Riek, U.; Scholz, R.; Konarev, P.; Rufer, A.; Suter, M.; Nazabal, A.; Ringler, P.; Chami, M.; Mueller, S.A.; Neumann, D.; Forstner, M.; Hennig, M.; Zenobi, R.; Engel, A.; Svergun, D.; Schlattner, U.; Wallimann, T.
    Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding (2008), J. Biol. Chem., 283, 18331-18343.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Rattus norvegicus
additional information cellular energy stress and other signals activate AMPK by various pathways, leading as a main consequence to compensatory measures that increase ATP generation and decrease ATP consumption Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of alpha1 subunit alone or in combination with other subunits in Escherichia coli Rattus norvegicus
expression of alpha2 subunit alone or in combination with other subunits in Escherichia coli Rattus norvegicus
expression of beta1 subunit alone or in combination with other subunits in Escherichia coli Rattus norvegicus
expression of beta2 subunit alone or in combination with other subunits in Escherichia coli Rattus norvegicus
expression of gamma1 subunit alone or in combination with other subunits in Escherichia coli Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus cellular energy stress and other signals activate AMPK by various pathways, leading as a main consequence to compensatory measures that increase ATP generation and decrease ATP consumption ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P54645 alpha1 subunit
-
Rattus norvegicus P80385 gamma1 subunit
-
Rattus norvegicus P80386 beta1 subunit
-
Rattus norvegicus P80386 beta2 subunit
-
Rattus norvegicus Q09137 alpha2 subunit
-

Purification (Commentary)

Purification (Comment) Organism
recombinant untagged protein by automated multidimensional purification including adsorption chromatography and gel filtration, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [peptide HMRSAMSGLHLVKRR] i.e. SAMS peptide Rattus norvegicus ADP + [peptide HMRSAMSGLHLVKRR] phosphate
-
 ?
additional information cellular energy stress and other signals activate AMPK by various pathways, leading as a main consequence to compensatory measures that increase ATP generation and decrease ATP consumption Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
trimer heterotrimer, complex structure determination and analysis by mass spectrometry, dynamic light and small-angle X-ray scattering and transmission electrom microscopy, modeling, overview Rattus norvegicus

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Rattus norvegicus
AMPK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus