Literature summary for 2.7.11.31 extracted from

Summermatter, S.; Mainieri, D.; Russell, A.P.; Seydoux, J.; Montani, J.P.; Buchala, A.; Solinas, G.; Dulloo, A.G.
Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase (2008), FASEB J., 22, 774-785.

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Activating Compound

Activating Compound	Comment	Organism	Structure
AMP	-	Rattus norvegicus
leptin	induces AMPK phosphorylation and activation	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	defective AMPK signaling reduces the rate of substrate cycling between de novo lipogenesis and lipid oxidation, leading to suppressed thermogenesis, which accelerates body fat recovery and furthermore sensitizes skeletal muscle to dietary fat-induced impairments in PI3K/AMPK signaling, overview	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [acetyl-CoA carboxylase]	Rattus norvegicus	phosphorylation at Ser79	ADP + [acetyl-CoA carboxylase] phosphate	-	?
additional information	Rattus norvegicus	the thrifty metabolism that favors fat storage after caloric restriction involves AMPK activity, AMPK signaling is diminished during refeeding after caloric restriction rats. Isocaloric refeeding with a high-fat diet, which exacerbates the suppression of thermogenesis, results in further reduction and in impaired AMPK phosphorylation, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	AMPK is activated by phosphorylation, induced e.g. by leptin	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	tibialis anterior and soleus muscles	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [acetyl-CoA carboxylase]	phosphorylation at Ser79	Rattus norvegicus	ADP + [acetyl-CoA carboxylase] phosphate	-	?
additional information	the thrifty metabolism that favors fat storage after caloric restriction involves AMPK activity, AMPK signaling is diminished during refeeding after caloric restriction rats. Isocaloric refeeding with a high-fat diet, which exacerbates the suppression of thermogenesis, results in further reduction and in impaired AMPK phosphorylation, overview	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Rattus norvegicus
AMPK	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)