Literature summary for 2.7.11.31 extracted from

Gao, F.; Qian, Y.J.; Chen, F.H.; Zhu, H.B.
Comparative analysis of stimulation and binding characteristics of adenosine analogs to AMP-activated protein kinase (2019), J. Asian Nat. Prod. Res., 21, 916-927 .

Search for more literature for 2.7.11.31

Activating Compound

Activating Compound	Comment	Organism	Structure
2',3',5'-tri-O-acetyl-N-(3-hydroxyphenyl)adenosine	EC50 of 0.3273 mM	Rattus norvegicus
AMP	EC50 of 0.2733 mM	Rattus norvegicus
additional information	adenosine (0.0001-0.5 mM) has no direct stimulating effect on enzyme activity	Rattus norvegicus
N-(3-hydroxyphenyl)adenosine	activates the enzyme with 1.4fold maximal activity at 0.001 mM	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 insect cells and Escherichia coli strain BL21 (DE3)	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	5 mM used in assay conditions	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	AMPKalpha1beta1gamma1 is the main isoform expressed in liver	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + HMRSAMSGLHLVKRR	-	Rattus norvegicus	ADP + ?	-	?

Subunits

Subunits	Comment	Organism
heterotrimer	-	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Rattus norvegicus
AMPK	-	Rattus norvegicus
AMPKalpha1beta1gamma1	isoform	Rattus norvegicus

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Release 2023.1 (January 2023)