Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside | AICAR, chronic AMPK activation with AICAR decreases blood pressure in rats displaying features of the insulin resistance syndrome | Rattus norvegicus | |
metformin | AMPK mediates the prevention of progression of heart failure by metformin. Protective effects of AMPK activation by metformin on cardiovascular disease | Canis lupus familiaris | |
additional information | diabetic rats treated with cilostazol, a selective inhibitor of phosphodiesterase 3, exhibit normalization of endothelial function that is linked to AMPK activation producing increased endothelial nitric oxide synthase activity and NO production. In the ischemic heart, both catalytic alpha1-isoform and alpha2-isoform of AMPK containing regulatory gamma1-isoform or gamma2-isoform are activated | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
drug development | AMPK represents an attractive therapeutic target for vascular disease treatment | Mus musculus |
drug development | AMPK represents an attractive therapeutic target for vascular disease treatment | Homo sapiens |
drug development | AMPK represents an attractive therapeutic target for vascular disease treatment | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
endothelial cell | - |
Rattus norvegicus | - |
heart | - |
Mus musculus | - |
heart | - |
Canis lupus familiaris | - |
heart | ischemic heart | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Mus musculus |
AMP-activated protein kinase | - |
Homo sapiens |
AMP-activated protein kinase | - |
Rattus norvegicus |
AMP-activated protein kinase | - |
Canis lupus familiaris |
AMPK | - |
Mus musculus |
AMPK | - |
Homo sapiens |
AMPK | - |
Rattus norvegicus |
AMPK | - |
Canis lupus familiaris |
Snf1 | homolog to mammalian AMPK | Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | AMPK gamma2 mutations are associated with hypertrophic cardiomyopathy | Homo sapiens |
physiological function | AMPK activation induces vasodilatation and blood flow regulation in wild-type mice and this effect is abolished in AMPKalpha1 knockout mice. Chronic activation of AMPK in vivo attenuates ROS-mediated c-Jun N-terminal kinase activation and endothelial dysfunction in response to angiotensin II, which is abrogated in mice lacking the endothelial isoform of AMPKalpha1 or peroxisome proliferator gamma coactivator-1alpha, a target of AMPK that controls mitochondrial biogenesis. AMPK-deficient mice demonstrate impairment in postischemic fatty acid oxidation. In the setting of systolic pressure overload, left ventricular hypertrophy ensues and AMPKalpha2 knockout mice exhibit significantly increased overload-induced ventricular hypertrophy and decreased left ventricular ejection fraction. Isolated hearts of AMPK-deleted mice show increased apoptosis and dysfunction after ischemia/reperfusion. Role of AMPK in regulation of apoptosis that is an important mechanism of heart failure | Mus musculus |
physiological function | AMPK activation inhibits ICAM-1 mediated migration of lymphocytes across primary microvascular endothelial cells | Rattus norvegicus |
physiological function | AMPK activation inhibits TNFa-stimulated leukocyte adhesion to aortic endothelial cells and ICAM-1 mediated migration of lymphocytes across primary microvascular endothelial cells | Homo sapiens |
physiological function | plays a crucial role in carbon catabolite repression in yeast. cRKIN1 gene product from rye can rescue SNF1 mutation | Saccharomyces cerevisiae |