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Information on EC 2.7.11.24 - mitogen-activated protein kinase and Organism(s) Homo sapiens and UniProt Accession P53779

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IUBMB Comments
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: P53779
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
mapk, p38, erk1/2, p38 mapk, map kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, p38 map kinase, p38mapk, mek1/2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
BMK1
266266
-
c-Jun N-terminal kinase
c-jun N-terminal kinase 1
c-Jun N-terminal kinase 2
c-Jun N-terminal kinase 3
c-Jun NH2-terminal kinase
247
-
c-jun NH2-terminal MAPK
247
-
cp38a
-
-
-
-
cp38b
-
-
-
-
CSAID binding protein
-
-
-
-
CSBP
-
-
-
-
Cytokine suppressive anti-inflammatory drug binding protein
-
-
-
-
ERK3
266268
-
ERK5
-
-
-
-
extracellular regulated kinase
266239, 266243
-
extracellular signal-regulated kinase
266239, 266243
-
extracellular signal-regulated kinase 1
266239
-
extracellular signal-regulated kinase 1/2
247
-
extracellular signal-regulated kinase 2
extracellular signal-regulated kinases-1/2
247
-
extracellular signal-related kinase
247
-
JNK 2
266252
-
JNK/SAPK1c
247
-
JNK1alpha1
266251
-
JNK2alpha2
266252
-
MAP kinase MXI2
-
-
-
-
MAP kinase p38 beta
-
-
-
-
MAP kinase p38 delta
-
-
-
-
MAP kinase p38 gamma
-
-
-
-
MAP kinase p38a
-
-
-
-
MAP kinase p38alpha
-
-
-
-
MAP kinase p38b
-
-
-
-
MAPK kinase
247
-
MAPK11
266267
-
MAPK12
296678
-
MAPK14
285973
-
MAPK3
266239
-
MAPK8
266251
-
MAPK9
266252
-
MEK
247
-
MEK1/2
247
-
mitogen-activated protein kinase
mitogen-activated protein kinase 1
266243
-
mitogen-activated protein kinase 10
266258
-
mitogen-activated protein kinase 11
266267
-
mitogen-activated protein kinase 13
266231
-
mitogen-activated protein kinase 3
266239
-
mitogen-activated protein kinase 4
266245
-
mitogen-activated protein kinase 6
266268
-
mitogen-activated protein kinase 7
266266
-
mitogen-activated protein kinase 8
266251
-
mitogen-activated protein kinase 9
266252
-
Mitogen-activated protein kinase p38 beta
-
-
-
-
Mitogen-activated protein kinase p38 delta
-
-
-
-
Mitogen-activated protein kinase p38 gamma
-
-
-
-
Mitogen-activated protein kinase p38a
-
-
-
-
Mitogen-activated protein kinase p38alpha
-
-
-
-
Mitogen-activated protein kinase p38b
-
-
-
-
mitogen-activated protein kinase p44erk1
266239
-
mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
247
-
p38 MAP kinase
p38 MAPK
p38 MAPKalpha
247
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p38 mitogen activated protein kinase
247
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p38 mitogen-activated protein kinase
p38 mitogen-activated protein kinase alpha
247
-
p38 protein
247
-
p38-2
266267
-
p38-delta mitogen-activated protein kinase
266231
-
p38-MAPK
247
-
p38alpha
p38alpha MAP kinase
247
-
p38alpha mitogen-activated protein kinase
P38alpha-MAPKAP kinase 2
247
-
p38b
-
-
-
-
p38beta
266267
-
p38delta
266231
-
p38gamma
296678
-
p38MAPK
247
-
p42
247
-
p44
247
-
p493F12 kinase
266258
-
p97MAPK
266268
-
SAPK
247
-
SAPK2A
-
-
-
-
SAPK2a/p38
247
-
SAPK2b/p38beta
247
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SAPK3/p38gamma
247
-
SAPK4
266231
-
SAPK4/p38delta
247
-
SAPKalphaI/JNK2
247
-
signal-regulated kinase 3
266268
-
stress-activated protein kinase 2a
-
-
-
-
stress-activated protein kinase-4
266231
-
additional information
247
the enzyme belongs to the MAPK superfamily of enzymes
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
phospho group transfer
PATHWAY SOURCE
PATHWAYS