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Information on EC 2.1.1.359 - [histone H3]-lysine36 N-trimethyltransferase

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IUBMB Comments
The enzyme, characterized from yeast, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. In mammals this activity is catalysed by two different enzymes, EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase and EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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3
+
a [histone H3]-L-lysine36
=
3
+
a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
Synonyms
ASH1, ASH1 HOMOLOG 2, ASHH2, histone H3 lysine 36 methyltransferase, histone H3 methyltransferase, histone H3K36 methyltransferase, histone lysine methyltransferase, histone lysine methyltransferases, histone methyltransferase, HMTase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
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overall reaction
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S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
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(1a)
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S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
show the reaction diagram
(1c)
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S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
(1b)
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