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Information on EC 2.1.1.359 - [histone H3]-lysine36 N-trimethyltransferase

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IUBMB Comments
The enzyme, characterized from yeast and mammals, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. cf. EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
ASH1, ASH1 HOMOLOG 2, ASHH2, CG1716, Ctr9, Dnmt3a, H3 K36 methyltransferase, H3K36 methyltransferase, H3K36 tri-methyltransferase, H3K36 trimethyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
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overall reaction
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S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
show the reaction diagram
(1a)
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S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
show the reaction diagram
(1c)
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S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
(1b)
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PATHWAY SOURCE
PATHWAYS
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