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Literature summary for 2.1.1.359 extracted from

  • Ho, T.H.; Park, I.Y.; Zhao, H.; Tong, P.; Champion, M.D.; Yan, H.; Monzon, F.A.; Hoang, A.; Tamboli, P.; Parker, A.S.; Joseph, R.W.; Qiao, W.; Dykema, K.; Tannir, N.M.; Castle, E.P.; Nunez-Nateras, R.; Teh, B.T.; Wang, J.; Walker, C.L.; Hung, M.C.; Jonasch, E.
    High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma (2016), Oncogene, 35, 1565-1574 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + [histone H3]-L-lysine36 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYW2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
renal cell carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + [histone H3]-L-lysine36 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
histone H3 lysine trimethyltransferase
-
 Homo sapiens
SETD2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme loss is associated with alterations in mRNA splicing in human clear cell renal cell carcinoma Homo sapiens