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Literature summary for 2.1.1.359 extracted from

  • Zhu, K.; Lei, P.J.; Ju, L.G.; Wang, X.; Huang, K.; Yang, B.; Shao, C.; Zhu, Y.; Wei, G.; Fu, X.D.; Li, L.; Wu, M.
    SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing (2017), Nucleic Acids Res., 45, 92-105 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL-21 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYW2
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
ubiquitination the speckle-type POZ protein/cullin 3 complex polyubiquitinates and regulates the stability of the enzyme in vivo and in vitro Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose 4 column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
H3K36 trimethyltransferase
-
 Homo sapiens
SET domain containing 2
-
 Homo sapiens
SETD2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme-mediated histone H3 lysine 36 trimethylation is implicated in the regulation of alternative splicing and DNA mismatch repair Homo sapiens