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Literature summary for 2.1.1.359 extracted from

  • Lee, Y.F.; Nimura, K.; Lo, W.N.; Saga, K.; Kaneda, Y.
    Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes (2014), PLoS ONE, 9, e106661 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BVE8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
H3K36 trimethyltransferase
-
 Mus musculus
Whsc1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme mutations are associated with Wolf-Hirschhorn syndrome, which is characterized by skeletal abnormalities. Enzyme-deficient embryos exhibit defects in ossification in the occipital bone and sternum. Enzyme knockdown in pre-osteoblast cells perturbs histone modification patterns in bone-related genes and leads to defects in bone differentiation Mus musculus
physiological function the enzyme regulates gene expression through Runt-related transcription factor 2, a transcription factor central to bone development, and p300, a histone acetyltransferase, to promote bone differentiation. The enzyme fine-tunes the expression of bone-related genes by acting as a modulator in balancing histone H3 lysine 36 trimethylation and histone acetylation. The enzyme is involved in osteoblast differentiation but not proliferation Mus musculus