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Literature summary for 2.1.1.359 extracted from

  • Li, Y.; Trojer, P.; Xu, C.F.; Cheung, P.; Kuo, A.; Drury, W.J.; Qiao, Q.; Neubert, T.A.; Xu, R.M.; Gozani, O.; Reinberg, D.
    The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate (2009), J. Biol. Chem., 284, 34283-34295.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
GST-SET domain fusion proteins are expressed in Escherichia coli, SET2-C is expressed in baculovirus insect cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens O96028 NSD2
-
Homo sapiens Q9BYW2 SETD2
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
Ni-NTA bead chromatography, glutathione bead chromatography, and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H4]-L-lysine44 histone H4 lysine-44 is the primary target of NSD2 in the case of octamer substrates, irrespective of the histones being native or recombinant Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H4]-N6,N6-dimethyl-L-lysine44
-
 ?
S-adenosyl-L-methionine + histone H3(K36) NSD2 shows specific targeting of histone H3 lysine-36, DNA acts as an allosteric effector of NSD2 such that H3K36 becomes the preferred target Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
histone lysine methyltransferase
-
 Homo sapiens
NSD2
-
 Homo sapiens
nuclear receptor SET domain 2
-
 Homo sapiens
SETD2
-
 Homo sapiens