Any feedback?
Literature summary for 2.1.1.359 extracted from
- Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2 (2015), Biochim. Biophys. Acta, 1850, 1842-1848.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
histone H3(peptide 21-44) | pH 9.0, 23°C | Homo sapiens | |
| 0.0033 | - |
S-adenosyl-L-methionine | cosubstrate recombinant nucleosome, pH 9.0, 23°C | Homo sapiens |  |
| 0.004 | - |
S-adenosyl-L-methionine | cosubstrate chicken nucleosome, pH 9.0, 23°C | Homo sapiens | |
| 0.0055 | - |
S-adenosyl-L-methionine | cosubstrate histone H3(peptide 21-44), pH 9.0, 23°C | Homo sapiens | |
| 0.0081 | - |
recombinant nucleosome | pH 9.0, 23°C | Homo sapiens | |
| 0.0089 | - |
chicken nucleosome | pH 9.0, 23°C | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9BYW2 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme mono- and dimethylates H3K36 and is inactive with H3K4 as substrate. Nucleosome containing histone H3 mutant K36A is not a substrate. Isoform SETD2 is able to trimethylate H3K36 in vitro | Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + chicken nucleosome | - |
Homo sapiens | S-adenosyl-L-homocysteine + chicken nucleosome N6-methyl-L-lysine | - |
? | |
| S-adenosyl-L-methionine + histone H3(K36) | - |
Homo sapiens | S-adenosyl-L-homocysteine + histone H3(K36) N6-methyl-L-lysine | - |
? | |
| S-adenosyl-L-methionine + histone H3(peptide 21-44) | - |
Homo sapiens | S-adenosyl-L-homocysteine + histone H3(peptide21-44) N6-methyl-L-lysine | - |
? | |
| S-adenosyl-L-methionine + recombinant nucleosome | - |
Homo sapiens | S-adenosyl-L-homocysteine + recombinant nucleosome N6-methyl-L-lysine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SETD2 | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0013 | - |
recombinant nucleosome | pH 9.0, 23°C | Homo sapiens | |
| 0.0031 | - |
histone H3(peptide 21-44) | pH 9.0, 23°C | Homo sapiens | |
| 0.0061 | - |
chicken nucleosome | pH 9.0, 23°C | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
