Literature summary for 2.1.1.359 extracted from

Xie, P.; Tian, C.; An, L.; Nie, J.; Lu, K.; Xing, G.; Zhang, L.; He, F.
Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes (2008), Cell. Signal., 20, 1671-1678.

Search for more literature for 2.1.1.359

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
NCI-H1299 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	SETD2 downregulates human ortholog of murine double min 2 protein expression by targeting its P2 promoter and then enhances p53 protein stability, enhances the transcriptional activity of p53, and regulates expression of select p53 target genes	Homo sapiens	?	-	?
S-adenosyl-L-methionine + histone H3(K36)	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
histone methyltransferase	-	Homo sapiens
huntingtin interacting protein B	-	Homo sapiens
HYPB	-	Homo sapiens
SET domain containing protein 2	a histone H3K36 trimethyltransferase protein	Homo sapiens
SETD2	-	Homo sapiens

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Release 2023.1 (January 2023)