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Literature summary for 2.1.1.359 extracted from

  • Tanaka, Y.; Kawahashi, K.; Katagiri, Z.; Nakayama, Y.; Mahajan, M.; Kioussis, D.
    Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression (2011), PLoS ONE, 6, e28171.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Protein Variants

Protein Variants Comment Organism
H2113K methyltransferase-deficient mutant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
hematopoietic stem cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H3(K36)
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ASH1
-
 Homo sapiens
histone H3 lysine 36 methyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction ASH1 knockdown causes reduced expression of Hox genes. Knockdown of ASH1 in K-562 cells in vitro causes increased expression of epsilon-globin gene and reduced expression of myelomonocytic markers GPIIb and GPIIIa, whereas knockdown of ASH1 in haematopoietic stem cells in vivo results in decreased number of macrophages and granulocytes Homo sapiens
physiological function ASH1 regulates endogenous Hox gene expression positively and negatively and is required for myelomonocytic differentiation. ASH1 and MLL1 co-operate in Hox promoter activation Homo sapiens