Reference on EC 2.1.1.359 - [histone H3]-lysine36 N-trimethyltransferase
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Xie, P.; Tian, C.; An, L.; Nie, J.; Lu, K.; Xing, G.; Zhang, L.; He, F.
Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes
Cell. Signal.
20
1671-1678
2008
Homo sapiens
Li, Y.; Trojer, P.; Xu, C.F.; Cheung, P.; Kuo, A.; Drury, W.J.; Qiao, Q.; Neubert, T.A.; Xu, R.M.; Gozani, O.; Reinberg, D.
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate
J. Biol. Chem.
284
34283-34295
2009
Homo sapiens (O96028), Homo sapiens (Q9BYW2), Homo sapiens
Grini, P.; Thorstensen, T.; Alm, V.; Vizcay-Barrena, G.; Windju, S.; Jorstad, T.; Wilson, Z.; Aalen, R.
The ASH1 HOMOLOG 2 (ASHH2) histone H3 methyltransferase is required for ovule and anther development in Arabidopsis
PLoS ONE
4
e7817
2009
Arabidopsis thaliana
Kim, D.W.; Kim, K.B.; Kim, J.Y.; Seo, S.B.
Characterization of a novel histone H3K36 methyltransferase setd3 in zebrafish
Biosci. Biotechnol. Biochem.
75
289-294
2011
Danio rerio (Q7SXS7), Danio rerio
Sun, C.; Fang, J.; Zhao, T.; Xu, B.; Zhang, F.; Liu, L.; Tang, J.; Zhang, G.; Deng, X.; Chen, F.; Qian, Q.; Cao, X.; Chu, C.
The histone methyltransferase SDG724 mediates H3K36me2/3 deposition at MADS50 and RFT1 and promotes flowering in rice
Plant Cell
24
3235-3247
2012
Oryza sativa Indica Group
Tanaka, Y.; Kawahashi, K.; Katagiri, Z.; Nakayama, Y.; Mahajan, M.; Kioussis, D.
Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression
PLoS ONE
6
e28171
2011
Homo sapiens
Eram, M.S.; Kuznetsova, E.; Li, F.; Lima-Fernandes, E.; Kennedy, S.; Chau, I.; Arrowsmith, C.H.; Schapira, M.; Vedadi, M.
Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2
Biochim. Biophys. Acta
1850
1842-1848
2015
Homo sapiens (Q9BYW2)
Wang, X.; Chen, J.; Xie, Z.; Liu, S.; Nolan, T.; Ye, H.; Zhang, M.; Guo, H.; Schnable, P.S.; Li, Z.; Yin, Y.
Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana
Mol. Plant
7
1303-1315
2014
Arabidopsis thaliana (Q2LAE1)
Lee, Y.F.; Nimura, K.; Lo, W.N.; Saga, K.; Kaneda, Y.
Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes
PLoS ONE
9
e106661
2014
Mus musculus
Li, F.; Mao, G.; Tong, D.; Huang, J.; Gu, L.; Yang, W.; Li, G.M.
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha
Cell
153
590-600
2013
Homo sapiens (Q9BYW2), Homo sapiens
Pfister, S.X.; Ahrabi, S.; Zalmas, L.P.; Sarkar, S.; Aymard, F.; Bachrati, C.Z.; Helleday, T.; Legube, G.; La Thangue, N.B.; Porter, A.C.; Humphrey, T.C.
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability
Cell Rep.
7
2006-2018
2014
Homo sapiens (Q9BYW2)
Zhang, K.; Haversat, J.M.; Mager, J.
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development
Dev. Biol.
383
15-27
2013
Mus musculus (E9Q5F9)
Bell, O.; Wirbelauer, C.; Hild, M.; Scharf, A.N.; Schwaiger, M.; MacAlpine, D.M.; Zilbermann, F.; van Leeuwen, F.; Bell, S.P.; Imhof, A.; Garza, D.; Peters, A.H.; Schuebeler, D.
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila
EMBO J.
26
4974-4984
2007
Drosophila melanogaster (Q9VYD1)
Du, H.N.; Fingerman, I.M.; Briggs, S.D.
Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4
Genes Dev.
22
2786-2798
2008
Saccharomyces cerevisiae (P46995), Saccharomyces cerevisiae BY4741 (P46995)
Pu, M.; Ni, Z.; Wang, M.; Wang, X.; Wood, J.G.; Helfand, S.L.; Yu, H.; Lee, S.S.
Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span
Genes Dev.
29
718-731
2015
Caenorhabditis elegans
Dhayalan, A.; Rajavelu, A.; Rathert, P.; Tamas, R.; Jurkowska, R.Z.; Ragozin, S.; Jeltsch, A.
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
J. Biol. Chem.
285
26114-26120
2010
Schizosaccharomyces pombe
Fuchs, S.M.; Kizer, K.O.; Braberg, H.; Krogan, N.J.; Strahl, B.D.
RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36
J. Biol. Chem.
287
3249-3256
2012
Saccharomyces cerevisiae (P46995)
Eram, M.S.; Bustos, S.P.; Lima-Fernandes, E.; Siarheyeva, A.; Senisterra, G.; Hajian, T.; Chau, I.; Duan, S.; Wu, H.; Dombrovski, L.; Schapira, M.; Arrowsmith, C.H.; Vedadi, M.
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein
J. Biol. Chem.
289
12177-12188
2014
Homo sapiens (Q9NQV7)
Hacker, K.E.; Fahey, C.C.; Shinsky, S.A.; Chiang, Y.J.; DiFiore, J.V.; Jha, D.K.; Vo, A.H.; Shavit, J.A.; Davis, I.J.; Strahl, B.D.; Rathmell, W.K.
Structure/function analysis of recurrent mutations in SETD2 protein reveals a critical and conserved role for a SET domain residue in maintaining protein stability and histone H3 Lys-36 trimethylation
J. Biol. Chem.
291
21283-21295
2016
Saccharomyces cerevisiae (P46995), Homo sapiens (Q9BYW2)
Li, L.; Wang, Y.
Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair
J. Biol. Chem.
292
11951-11959
2017
Homo sapiens (Q9BYW2)
Larschan, E.; Alekseyenko, A.A.; Gortchakov, A.A.; Peng, S.; Li, B.; Yang, P.; Workman, J.L.; Park, P.J.; Kuroda, M.I.
MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism
Mol. Cell
28
121-133
2007
Drosophila melanogaster (Q9VYD1)
Xu, L.; Zhao, Z.; Dong, A.; Soubigou-Taconnat, L.; Renou, J.P.; Steinmetz, A.; Shen, W.H.
Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana
Mol. Cell. Biol.
28
1348-1360
2008
Arabidopsis thaliana (Q2LAE1)
Lin, L.J.; Minard, L.V.; Johnston, G.C.; Singer, R.A.; Schultz, M.C.
Asf1 can promote trimethylation of H3 K36 by Set2
Mol. Cell. Biol.
30
1116-1129
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Nimura, K.; Ura, K.; Shiratori, H.; Ikawa, M.; Okabe, M.; Schwartz, R.J.; Kaneda, Y.
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome
Nature
460
287-291
2009
Mus musculus (Q8BVE8), Mus musculus
Huang, H.; Weng, H.; Zhou, K.; Wu, T.; Zhao, B.S.; Sun, M.; Chen, Z.; Deng, X.; Xiao, G.; Auer, F.; Klemm, L.; Wu, H.; Zuo, Z.; Qin, X.; Dong, Y.; Zhou, Y.; Qin, H.; Tao, S.; Du, J.; Liu, J.; Lu, Z.; Yin, H.; Mesquita, A.; Yuan, C.L.; Hu, Y.C.; Sun, W.; Su, R.; Dong, L.; Shen, C.; Li, C.; Qing, Y.; Jiang, X.; Wu, X.; Sun, M.
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Nature
567
414-419
2019
Homo sapiens (Q9BYW2)
Carvalho, S.; Raposo, A.C.; Martins, F.B.; Grosso, A.R.; Sridhara, S.C.; Rino, J.; Carmo-Fonseca, M.; de Almeida, S.F.
Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription
Nucleic Acids Res.
41
2881-2893
2013
Homo sapiens (Q9BYW2)
Zhu, K.; Lei, P.J.; Ju, L.G.; Wang, X.; Huang, K.; Yang, B.; Shao, C.; Zhu, Y.; Wei, G.; Fu, X.D.; Li, L.; Wu, M.
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing
Nucleic Acids Res.
45
92-105
2017
Homo sapiens (Q9BYW2)
Ho, T.H.; Park, I.Y.; Zhao, H.; Tong, P.; Champion, M.D.; Yan, H.; Monzon, F.A.; Hoang, A.; Tamboli, P.; Parker, A.S.; Joseph, R.W.; Qiao, W.; Dykema, K.; Tannir, N.M.; Castle, E.P.; Nunez-Nateras, R.; Teh, B.T.; Wang, J.; Walker, C.L.; Hung, M.C.; Jonasch, E.
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma
Oncogene
35
1565-1574
2016
Homo sapiens (Q9BYW2)
Jin, J.; Shi, J.; Liu, B.; Liu, Y.; Huang, Y.; Yu, Y.; Dong, A.
MORF-RELATED GENE702, a reader protein of trimethylated histone H3 lysine 4 and histone H3 lysine 36, is involved in brassinosteroid-regulated growth and flowering time control in rice
Plant Physiol.
168
1275-1285
2015
Oryza sativa
Sein, H.; Vrv, S.; Kristjuhan, A.
Distribution and maintenance of histone H3 lysine 36 trimethylation in transcribed locus lysine 36 trimethylation in transcribed locus
PLoS ONE
10
e0120200
2015
Saccharomyces cerevisiae
Lee, Y.F.; Nimura, K.; Lo, W.N.; Saga, K.; Kaneda, Y.
Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes
PLoS ONE
9
e106661
2014
Mus musculus (Q8BVE8)
Gautam, D.; Johnson, B.A.; Mac, M.; Moody, C.A.
SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle
PLoS Pathog.
14
e1007367
2018
Human papillomavirus type 16, human papillomavirus 31
Hu, M.; Sun, X.J.; Zhang, Y.L.; Kuang, Y.; Hu, C.Q.; Wu, W.L.; Shen, S.H.; Du, T.T.; Li, H.; He, F.; Xiao, H.S.; Wang, Z.G.; Liu, T.X.; Lu, H.; Huang, Q.H.; Chen, S.J.; Chen, Z.
Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
Proc. Natl. Acad. Sci. USA
107
2956-2961
2010
Mus musculus (E9Q5F9), Homo sapiens (Q9BYW2)
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