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Literature summary for 2.1.1.359 extracted from

  • Bell, O.; Wirbelauer, C.; Hild, M.; Scharf, A.N.; Schwaiger, M.; MacAlpine, D.M.; Zilbermann, F.; van Leeuwen, F.; Bell, S.P.; Imhof, A.; Garza, D.; Peters, A.H.; Schuebeler, D.
    Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila (2007), EMBO J., 26, 4974-4984 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Drosophila melanogaster overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VYD1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Drosophila melanogaster 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
CG1716
-
 Drosophila melanogaster
HYPB
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction reduction of histone H3 lysine 36 trimethylation is lethal in Drosophila larvae and leads to elevated levels of acetylation, specifically at lysine 16 of histone H4 Drosophila melanogaster
physiological function the enzyme is essential for Drosophila melanogaster development Drosophila melanogaster