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Literature summary for 2.1.1.359 extracted from

  • Lee, Y.F.; Nimura, K.; Lo, W.N.; Saga, K.; Kaneda, Y.
    Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes (2014), PLoS ONE, 9, e106661.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.359

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
C3H10T1/2 cell
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 Mus musculus
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MC3T3-E1 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H3(K36)
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 Mus musculus S-adenosyl-L-homocysteine + histone H3(K36) N6-methyl-L-lysine transfer of three methyl groups ?

Synonyms

Synonyms Comment Organism
Whsc1
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 Mus musculus
Wolf-Hirschhorn Syndrome candidate 1
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 Mus musculus

General Information

General Information Comment Organism
physiological function Whsc1-/- embryos exhibit defects in ossification in the occipital bone and sternum. Whsc1 knockdown in pre-osteoblast cells perturbs histone modification patterns in bone-related genes and leads to defects in bone differentiation. Whsc1 increases the association of p300 with Runx2, activating the bone-related genes osteopontin and collagen type Ia, and Whsc1 suppresses the overactivation of these genes via H3K36 trimethylation Mus musculus