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Disease on EC 2.1.1.359 - [histone H3]-lysine36 N-trimethyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Adenocarcinoma
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis.
Arthritis, Rheumatoid
Altered gene expression profiles of histone lysine methyltransferases and demethylases in rheumatoid arthritis synovial fibroblasts.
Breast Neoplasms
An epigenomic approach to therapy for tamoxifen-resistant breast cancer.
An open environment CT-US fusion for tissue segmentation during interventional guidance.
Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.
DACH1 suppresses breast cancer as a negative regulator of CD44.
Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver.
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.
Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer.
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model.
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Paclitaxel (Taxol): an inhibitor of angiogenesis in a highly vascularized transgenic breast cancer.
Permeability across a novel microfluidic blood-tumor barrier model.
Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.
Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells.
Spatial and temporal-controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors.
The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.
Carcinogenesis
Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer.
DACH1 suppresses breast cancer as a negative regulator of CD44.
Euchromatic histone methyltransferase 2 inhibitor, BIX-01294, sensitizes human promyelocytic leukemia HL-60 and NB4 cells to growth inhibition and differentiation.
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention.
Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.
Roles of histone methyl-modifying enzymes in development and progression of cancer.
WHSC1 acts as a prognostic indicator and functions as an oncogene in cervical cancer.
Carcinoma
An antisense oligodeoxynucleotide to p21(Waf1/Cip1) causes apoptosis in human breast cancer cells.
Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma.
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.
Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation.
MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer.
miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma.
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Carcinoma, Ductal
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Carcinoma, Hepatocellular
Comprehensive Bioinformatics Analysis of Key Methyltransferases and Demethylases for Histone Lysines in Hepatocellular Carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Carcinoma, Non-Small-Cell Lung
The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer.
Carcinoma, Renal Cell
Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma.
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.
Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation.
miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma.
Chagas Disease
Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Cleft Palate
Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis.
Colitis
Rebooting the microbiome.
Dwarfism
H3K36 methylation is critical for brassinosteroid-regulated plant growth and development in rice.
Head and Neck Neoplasms
Epigenetic perspective into head and neck cancer through in silico gene expression profiling of histone lysine methyltransferases.
Hepatitis B
An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.
Infections
A human gut ecosystem protects against C. difficile disease by targeting TcdA.
Administration of defined microbiota is protective in a murine Salmonella infection model.
Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi.
Leishmaniasis, Visceral
Leishmania donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides + IFN-?)/M(IL-10) Polarization.
Leukemia
Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia.
Alternative translation initiation generates the N-terminal truncated form of RUNX1 that retains hematopoietic activity.
Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T cell leukemia.
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.
Isolation of MLL1 Inhibitory RNA Aptamers.
Leukemia, T-Cell
Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25.
Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T cell leukemia.
Lung Neoplasms
Lung tumor-associated dendritic cell-derived resistin promoted cancer progression by increasing Wolf-Hirschhorn syndrome candidate 1/Twist pathway.
The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer.
Lymphoma
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Measles
Success of measles virotherapy in ATL depends on type I interferon secretion and responsiveness.
Multiple Myeloma
A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription.
Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.
Multiple Sclerosis
Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta).
Myelodysplastic Syndromes
SET Domain Containing 2 Deficiency in Myelodysplastic Syndrome.
Neoplasm Metastasis
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.
Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib.
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.
The milk protein ?-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.
Tumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo.
Neoplasms
A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism.
An Imaging-Driven Model for Liposomal Stability and Circulation.
An open environment CT-US fusion for tissue segmentation during interventional guidance.
An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation.
Cancers and the NSD family of histone lysine methyltransferases.
CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.
CRISPR/Cas9-mediated knockout of NSD1 suppresses the hepatocellular carcinoma development via the NSD1/H3/Wnt10b signaling pathway.
DACH1 suppresses breast cancer as a negative regulator of CD44.
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.
Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling.
Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.
Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer.
Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.
In vivo validation and 3D visualization of broadband ultrasound molecular imaging.
Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia.
Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression.
KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells.
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Long non-coding RNAs MACC1-AS1 and FOXD2-AS1 mediate NSD2-induced cisplatin resistance in esophageal squamous cell carcinoma.
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis.
Magnetic resonance thermometry at 7T for real-time monitoring and correction of ultrasound induced mild hyperthermia.
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model.
Measles Virotherapy in a Mouse Model of Adult T cell Leukemia/Lymphoma.
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Molecular pathways in renal cell carcinoma: recent advances in genetics and molecular biology.
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.
Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells.
Role of several histone lysine methyltransferases in tumor development.
Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.
SETD2: an epigenetic modifier with tumor suppressor functionality.
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Spatial and temporal-controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors.
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.
Success of measles virotherapy in ATL depends on type I interferon secretion and responsiveness.
Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives.
The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.
The milk protein ?-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.
The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.
Trityl-based EPR probe with enhanced sensitivity to oxygen.
Tumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo.
Unsafe SETs: histone lysine methyltransferases and cancer.
Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation.
Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Overweight
Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver.
Prostatic Neoplasms
Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer.
Sarcoma
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Squamous Cell Carcinoma of Head and Neck
Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.
Triple Negative Breast Neoplasms
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Wolf-Hirschhorn Syndrome
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
A microdeletion proximal of the critical deletion region is associated with mild Wolf-Hirschhorn syndrome.
A Scalable Platform for Producing Recombinant Nucleosomes with Codified Histone Methyltransferase Substrate Preferences.
A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription.
Functional characterization of the zebrafish WHSC1-related gene, a homolog of human NSD2.
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas.
Lung tumor-associated dendritic cell-derived resistin promoted cancer progression by increasing Wolf-Hirschhorn syndrome candidate 1/Twist pathway.
Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis.
Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.
WHSC1 acts as a prognostic indicator and functions as an oncogene in cervical cancer.
WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck.
WHSC1/NSD2 regulates immune infiltration in prostate cancer.
Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation.
Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.
Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.
[histone h3]-lysine36 n-trimethyltransferase deficiency
SET Domain Containing 2 Deficiency in Myelodysplastic Syndrome.