Literature summary for 2.1.1.359 extracted from

Larschan, E.; Alekseyenko, A.A.; Gortchakov, A.A.; Peng, S.; Li, B.; Yang, P.; Workman, J.L.; Park, P.J.; Kuroda, M.I.
MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism (2007), Mol. Cell, 28, 121-133 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3 S-adenosyl-L-methionine + [histone H3]-L-lysine36	Drosophila melanogaster	overall reaction	3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36	-	?
S-adenosyl-L-methionine + [histone H3]-L-lysine36	Drosophila melanogaster	-	S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine36	-	?
S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine36	Drosophila melanogaster	-	S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36	-	?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine36	Drosophila melanogaster	-	S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9VYD1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
larva	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3 S-adenosyl-L-methionine + [histone H3]-L-lysine36	overall reaction	Drosophila melanogaster	3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36	-	?
S-adenosyl-L-methionine + [histone H3]-L-lysine36	-	Drosophila melanogaster	S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine36	-	?
S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine36	-	Drosophila melanogaster	S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36	-	?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine36	-	Drosophila melanogaster	S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36	-	?

Synonyms

Synonyms	Comment	Organism
CG1716	-	Drosophila melanogaster
H3K36me3 methyltransferase	-	Drosophila melanogaster
SET2	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
physiological function	the enzyme is required for viability and methylation of [histone H3]-L-lysine36 in Drosophila melanogaster	Drosophila melanogaster

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Release 2023.1 (January 2023)