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Literature summary for 2.1.1.359 extracted from

  • Larschan, E.; Alekseyenko, A.A.; Gortchakov, A.A.; Peng, S.; Li, B.; Yang, P.; Workman, J.L.; Park, P.J.; Kuroda, M.I.
    MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism (2007), Mol. Cell, 28, 121-133 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + [histone H3]-L-lysine36 Drosophila melanogaster overall reaction 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
?
S-adenosyl-L-methionine + [histone H3]-L-lysine36 Drosophila melanogaster
-
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine36
-
?
S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine36 Drosophila melanogaster
-
S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine36 Drosophila melanogaster
-
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VYD1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + [histone H3]-L-lysine36 overall reaction Drosophila melanogaster 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
?
S-adenosyl-L-methionine + [histone H3]-L-lysine36
-
Drosophila melanogaster S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine36
-
?
S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
Drosophila melanogaster S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine36
-
Drosophila melanogaster S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
?

Synonyms

Synonyms Comment Organism
SET2
-
Drosophila melanogaster
H3K36me3 methyltransferase
-
Drosophila melanogaster
CG1716
-
Drosophila melanogaster

General Information

General Information Comment Organism
physiological function the enzyme is required for viability and methylation of [histone H3]-L-lysine36 in Drosophila melanogaster Drosophila melanogaster