Information on EC 4.2.1.84 - nitrile hydratase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
4.2.1.84
-
RECOMMENDED NAME
GeneOntology No.
nitrile hydratase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aliphatic amide = a nitrile + H2O
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C-O bond cleavage by elimination of water
additional information
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
acrylonitrile degradation I
-
-
aldoxime degradation
-
-
Aminobenzoate degradation
-
-
degradation of aromatic, nitrogen containing compounds
-
-
Fluorobenzoate degradation
-
-
IAA biosynthesis
-
-
indole-3-acetate biosynthesis II
-
-
indole-3-acetate biosynthesis IV (bacteria)
-
-
Microbial metabolism in diverse environments
-
-
Styrene degradation
-
-
Tryptophan metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
aliphatic-amide hydro-lyase (nitrile-forming)
Acts on short-chain aliphatic nitriles, converting them into the corresponding amides. Does not act on these amides or on aromatic nitriles. cf. EC 3.5.5.1 nitrilase.
CAS REGISTRY NUMBER
COMMENTARY hide
82391-37-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain RAPc8
-
-
Manually annotated by BRENDA team
strain RAPc8
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-
Manually annotated by BRENDA team
strain B-261
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Alcaligenes faecalis CCTCC M 208168
-
-
-
Manually annotated by BRENDA team
contain at least two NHases, it is currently not known whether the aeroplysinin-1-hydrating enzyme is of sponge origin or produced by its symbiotic microorganisms
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-
Manually annotated by BRENDA team
strain J-1
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-
Manually annotated by BRENDA team
alpha-subunit; strain SC-J05-1; beta-subunit; strain SC-J05-1
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-
Manually annotated by BRENDA team
alpha-subunit; strain SC-J05-1; beta-subunit; strain SC-J05-1
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-
Manually annotated by BRENDA team
strain RAPc8, expression in Escherichia coli
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Bacillus subtilis CCTCC M 206038
-
-
-
Manually annotated by BRENDA team
Comamonas oleophilus
strain ATCC 15963
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-
Manually annotated by BRENDA team
Corynebacterium nitrilophilus
-
-
-
Manually annotated by BRENDA team
strain ZBB-41
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-
Manually annotated by BRENDA team
strain ZBB-41
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-
Manually annotated by BRENDA team
C5
-
-
Manually annotated by BRENDA team
strain N-774
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Mesorhizobium sp.
strain F28, isolated from a wastewater treatment system in a polyacrylonitrile fibre factory
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-
Manually annotated by BRENDA team
Mesorhizobium sp. BNC1
strain F28, isolated from a wastewater treatment system in a polyacrylonitrile fibre factory
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Manually annotated by BRENDA team
no activity in Arabidopsis thaliana
strain CYP79A1, genetic modification
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Manually annotated by BRENDA team
strain 108
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Manually annotated by BRENDA team
strain ATCC 12485
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Manually annotated by BRENDA team
strain 5B
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Manually annotated by BRENDA team
gene nit-30
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Rhodococcus boritolerans CCTCC M 208108
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Manually annotated by BRENDA team
strain 870-AN019, expression of enzyme in Escherichia coli
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-
Manually annotated by BRENDA team
strain N-771
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Manually annotated by BRENDA team
strain N4
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-
Manually annotated by BRENDA team
strain N771
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Manually annotated by BRENDA team
strain DSM43985
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Manually annotated by BRENDA team
strain DSM43985
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Manually annotated by BRENDA team
strain: S82-2
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Manually annotated by BRENDA team
strain S85-2, enzyme activity is induced by acetonitrile, acetamide, propionamide, urea
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain IFO 15564
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Manually annotated by BRENDA team
strain NCIMB 11216
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Manually annotated by BRENDA team
Rhodococcus ruber CCTCC M 206040
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Manually annotated by BRENDA team
strain CGMCC3090
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Manually annotated by BRENDA team
strain 7
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Manually annotated by BRENDA team
strain AJ270
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Manually annotated by BRENDA team
strain J1
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Manually annotated by BRENDA team
strain N-774
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain N771
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Manually annotated by BRENDA team
Rhodococcus sp. Novo SP361
strain Novo SP361
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Manually annotated by BRENDA team
strain R312
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Manually annotated by BRENDA team
strain RHA1
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Manually annotated by BRENDA team
strain SHZ-1
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Manually annotated by BRENDA team
Serratia marcescens CCTCC M 208231
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Manually annotated by BRENDA team
strain ZJB-09104
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1R,3R)-2,2-dibromo-3-phenylcyclopropanecarbonitrile + H2O
(1R,3R)-2,2-dibromo-3-phenylcyclopropanecarbamide
show the reaction diagram
(1R,3R)-3-phenylcyclopropanecarbonitrile + H2O
(1R,3R)-3-phenylcyclopropanecarbamide
show the reaction diagram
(1R,3S)-3-phenylcyclopropanecarbonitrile + H2O
(1R,3S)-3-phenylcyclopropanecarbamide
show the reaction diagram
(1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarbonitrile + H2O
(1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarbamide
show the reaction diagram
(2R)-2-hydroxy-3-methylbutanenitrile + H2O
(2R)-2-hydroxy-3-methylbutanamide
show the reaction diagram
-
-
-
-
?
(2R)-2-hydroxybut-3-enenitrile + H2O
(2R)-2-hydroxybut-3-enamide
show the reaction diagram
-
-
-
-
?
(2R)-2-hydroxybutanenitrile + H2O
(2R)-2-hydroxybutanamide
show the reaction diagram
-
-
-
-
?
(2R)-2-hydroxyhexanenitrile + H2O
(2R)-2-hydroxyhexanamide
show the reaction diagram
-
-
-
-
?
(2R)-2-hydroxypentanenitrile + H2O
(2R)-2-hydroxypentanamide
show the reaction diagram
-
-
-
-
?
(R)-2-chloromandelonitrile + H2O
(R)-2-chloromandelamide
show the reaction diagram
at 100% the rate of 2-hydroxy-4-phenylbutyronitrile
-
-
?
(R,S)-2-(4-nitrophenyl)-propionitrile + H2O
?
show the reaction diagram
-
39% conversion
-
-
?
(R,S)-2-bromopropionitrile + H2O
?
show the reaction diagram
-
47% conversion
-
-
?
(R,S)-2-chloropropionitrile + H2O
?
show the reaction diagram
-
48% conversion
-
-
?
(R,S)-2-phenylbutyronitrile + H2O
?
show the reaction diagram
-
51% conversion
-
-
?
(R,S)-2-phenylpropionitrile + H2O
?
show the reaction diagram
-
43% conversion
-
-
?
(R,S)-3-oxo-2-phenylbutyronitrile + H2O
?
show the reaction diagram
-
43% conversion
-
-
?
(S)-3-benzoyloxypentanedinitrile + H2O
3-amino-1-(2-amino-2-oxoethyl)-3-oxopropyl benzoate
show the reaction diagram
-
substrate conversion: 38.5%, enantiomeric excess: 68.2
-
-
r
1,1,3,3,-tetramethylbutylisonitrile + H2O
1,1,3,3,-tetramethylisobutylamide
show the reaction diagram
1-(4-bromo-phenyl)-aziridine-2-carbonitrile + H2O
1-(4-bromophenyl)aziridine-2-carboxamide
show the reaction diagram
-
-
-
-
r
1-(4-methoxy-phenyl)-aziridine-2-carbonitrile + H2O
1-(4-methoxyphenyl)aziridine-2-carboxamide
show the reaction diagram
-
-
-
-
r
1-naphthylnitrile + H2O
1-naphthylamide
show the reaction diagram
17alpha-cyanomethyl-17beta-hydroxy-estra-4,9-dien-3-one + H2O
17alpha-acetamido-estra-1,3,5(10),9(11)-tetraene-3,17beta-diol
show the reaction diagram
-
the steroidal group is metabolized very slowly
-
?
2(R)-(4-chlorophenyl)-3-methylbutyronitrile + H2O
2(R)-(4-chloro-phenyl)-3-methyl-butyramide
show the reaction diagram
2(S)-(4-chlorophenyl)-3-methylbutyronitrile + H2O
2(S)-(4-chloro-phenyl)-3-methyl-butyramide
show the reaction diagram
2,2-dimethylcyclopropanecarbonitrile + H2O
2,2-dimethylcyclopropanecarbamide
show the reaction diagram
2,2-dimethylcyclopropanecarbonitrile + H2O
2,2-dimethylcyclopropanecarboxamide
show the reaction diagram
2,2-dimethylcyclopropanecarbonitrile + H2O
?
show the reaction diagram
-
-
-
?
2,3,4,5,6-pentafluorobenzonitrile + H2O
2,3,4,5,6-pentafluorobenzamide
show the reaction diagram
-
-
-
-
?
2,3-dihydro-benzo(1,4)dioxine-2-carbonitrile + H2O
2,3-dihydro-1,4-benzodioxine-2-carboxamide
show the reaction diagram
-
substrate conversion: 45.1%, enantiomeric excess: 0
-
-
r
2,6-dichlorobenzamide + H2O
2,6-dichlorobenzoic acid
show the reaction diagram
2,6-difluorobenzonitrile + H2O
2,6-difluorobenzamide
show the reaction diagram
-
-
-
-
?
2-amino-2,3-dimethylbutyronitrile + H2O
2-amino-2,3-dimethylbutyramide
show the reaction diagram
2-aminopropionitrile + H2O
2-aminopropionic acid amide
show the reaction diagram
-
90% of the activity with propionitrile
-
-
?
2-bromobenzonitrile + H2O
2-bromobenzamide
show the reaction diagram
-
-
-
-
ir
2-chlorobenzaldehyde + HCN + H2O
(R)-2-chloromandelonitrile
show the reaction diagram
-
-
90% conversion to alpha-hydroxy nitrile
-
?
2-chlorobenzonitrile + H2O
2-chlorobenzamide
show the reaction diagram
-
-
-
-
ir
2-cyanopyridine + H2O
pyridine-2-carbamide
show the reaction diagram
2-fluorobenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
100% conversion to alpha-hydroxy nitrile
-
?
2-fluorobenzonitrile + H2O
2-fluorobenzamide
show the reaction diagram
-
-
-
-
ir
2-furonitrile + H2O
2-furoamide
show the reaction diagram
2-hydroxy-4-phenylbutanenitrile + H2O
?
show the reaction diagram
-
-
-
?
2-hydroxy-4-phenylbutyronitrile + H2O
2-hydroxy-4-phenylbutyramide
show the reaction diagram
-
-
-
?
2-hydroxymethyl-3-phenyl-propionitrile + H2O
2-benzyl-3-hydroxypropanamide
show the reaction diagram
-
-
-
-
r
2-hydroxypropionitrile + H2O
2-hydroxypropionic acid amide
show the reaction diagram
2-methoxybenzonitrile + H2O
2-methoxybenzamide
show the reaction diagram
-
-
-
-
ir
2-methoxymethyl-3-phenyl-propionitrile + H2O
2-benzyl-3-methoxypropanamide
show the reaction diagram
-
-
-
-
r
2-methyl-3-butenenitrile + H2O
?
show the reaction diagram
2-methylbenzonitrile + H2O
2-methylbenzamide
show the reaction diagram
-
-
-
-
ir
2-naphthylacetonitrile + H2O
2-naphthylacetamide
show the reaction diagram
2-nitro-5-thiocyanato-benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
2-nitrobenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
20% conversion to alpha-hydroxy nitrile
-
?
2-phenylacetonitrile + H2O
2-phenylpropionamide
show the reaction diagram
-
-
-
-
?
2-phenylbutyronitrile + H2O
2-phenylbutyramide
show the reaction diagram
-
used as well as phenylacetonitrile
-
-
?
2-phenylglycinonitrile + H2O
aminoacetamide
show the reaction diagram
-
used as well as phenylacetonitrile
-
-
?
2-phenylpropionitrile + H2O
2-phenylpropionamide
show the reaction diagram
3,4,5-trimethoxybenzonitrile + H2O
3,4,5-trimethoxybenzamide
show the reaction diagram
3,4-dimethoxybenzonitrile + H2O
3,4-dimethoxybenzaldehyde
show the reaction diagram
3,4-dimethoxybenzonitrile + H2O
3,4-dimethoxybenzaldehyde + HCN
show the reaction diagram
3-(1-cyanoethyl)benzoic acid + H2O
?
show the reaction diagram
3-(trifluoromethyl)benzonitrile + H2O
3-(trifluoromethyl)benzamide
show the reaction diagram
-
5% conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
3-(trifluoromethyl)pyridine-4-carbonitrile + H2O
3-(trifluoromethyl)pyridine-4-carboxamide
show the reaction diagram
-
-
-
-
ir
3-allyloxy-4-phenyl-butyronitrile + H2O
4-phenyl-3-(prop-2-en-1-yloxy)butanamide
show the reaction diagram
-
-
-
-
r
3-aminopropionitrile + H2O
3-aminopropionic acid amide
show the reaction diagram
-
2.7% of the activity with propionitrile
-
-
?
3-benzoyloxyglutaronitrile + H2O
(S)-3-benzoyloxy-4-cyanobutyramide
show the reaction diagram
3-benzyloxy-3-vinyl-propionitrile + H2O
3-(benzyloxy)pent-4-enamide
show the reaction diagram
-
-
-
-
r
3-benzyloxy-pentanonitrile + H2O
3-(benzyloxy)pentanamide
show the reaction diagram
-
-
-
-
r
3-benzyloxyglutaronitrile + H2O
3-benzyloxy-4-cyanobutyramide
show the reaction diagram
3-bromobenzonitrile + H2O
3-bromobenzamide
show the reaction diagram
-
5% conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
3-chlorobenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
100% conversion to alpha-hydroxy nitrile
-
?
3-chlorobenzonitrile + H2O
3-chlorobenzamide
show the reaction diagram
3-cyanopyridine + H2O
nicotinamide
show the reaction diagram
3-cyanopyridine + H2O
pyridine-3-carbamide
show the reaction diagram
3-cyanopyridine + H2O
pyridine-3-carboxamide
show the reaction diagram
3-fluorobenzonitrile + H2O
3-fluorobenzamide
show the reaction diagram
-
above 99.9% conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
3-hydroxy-3-phenylpropionitrile + H2O
3-hydroxy-3-phenylpropionamide
show the reaction diagram
-
-
-
-
?
3-hydroxybenzonitrile + H2O
3-hydroxybenzamide
show the reaction diagram
3-hydroxybutryronitrile + H2O
3-hydroxybutyramide
show the reaction diagram
3-hydroxypropionitrile + H2O
3-hydroxypropanamide
show the reaction diagram
-
35% of the activity with propionitrile
-
-
?
3-hydroxypropionitrile + H2O
3-hydroxypropionamide
show the reaction diagram
3-hydroxyvaleronitrile + H2O
3-hydroxyvaleramide
show the reaction diagram
3-methoxybenzonitrile + H2O
3-methoxybenzamide
show the reaction diagram
-
3% conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
3-methylbenzonitrile + H2O
3-methylbenzamide
show the reaction diagram
3-phenoxymandelonitrile + H2O
3-phenoxymandelamine
show the reaction diagram
at 10% the rate of 2-hydroxy-4-phenylbutyronitrile
-
-
?
3-phenylpropanenitrile + H2O
3-phenylpropanamide
show the reaction diagram
3-phenylpropionitrile + H2O
3-phenylpropionamide
show the reaction diagram
-
used as well as phenylacetonitrile
-
-
?
3-tolunitrile + H2O
?
show the reaction diagram
4-(trifluoromethyl)benzonitrile + H2O
4-(trifluoromethyl)benzamide
show the reaction diagram
4-acetylbenzonitrile + H2O
4-acetylbenzamide
show the reaction diagram
4-aminobenzonitrile + H2O
4-aminobenzamide
show the reaction diagram
4-bromobenzonitrile + H2O
4-bromobenzamide
show the reaction diagram
-
-
-
-
ir
4-bromobenzonitrile + H2O
4-bromobenzonitrile
show the reaction diagram
-
above 99% conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
4-chloro-3-hydroxybutanenitrile + H2O
?
show the reaction diagram
-
-
-
?
4-chloro-3-hydroxybutyronitrile + H2O
4-chloro-3-hydroxybutyramide
show the reaction diagram
-
the following reaction by an amidase leads to the correspondend carboxylic acid
-
-
?
4-chlorobenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
100% conversion to alpha-hydroxy nitrile
-
?
4-chlorobenzonitrile + H2O
4-chlorbenzamide
show the reaction diagram
-
-
-
-
ir
4-chlorobenzonitrile + H2O
4-chlorobenzamide
show the reaction diagram
4-chlorobutyronitrile + H2O
4-chlorobutyramide
show the reaction diagram
-
-
-
?
4-cyanobenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
100% conversion to alpha-hydroxy nitrile
-
?
4-cyanobenzoic acid + H2O
4-(aminocarbonyl)benzoic acid
show the reaction diagram
-
-
-
-
?
4-cyanopyridine + H2O
isonicotinamide
show the reaction diagram
4-cyanopyridine + H2O
pyridine-4-carbamide
show the reaction diagram
4-fluorobenzonitrile + H2O
4-fluorbenzamide
show the reaction diagram
-
-
-
-
ir
4-fluorobenzonitrile + H2O
4-fluorobenzamide
show the reaction diagram
-
above 99.9% conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
4-hydroxybenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
55% conversion to alpha-hydroxy nitrile
-
?
4-hydroxybenzonitrile + H2O
4-hydroxybenzamide
show the reaction diagram
-
-
-
-
?
4-hydroxybenzonitrile + H2O
4-hydroxybenzoic acid amide
show the reaction diagram
4-hydroxyphenylacetonitrile + H2O
4-hydroxyphenylacetamide
show the reaction diagram
4-methoxybenzonitrile + H2O
4-methoxybenzamide
show the reaction diagram
4-methylbenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
51% conversion to alpha-hydroxy nitrile
-
?
4-methylbenzonitrile + H2O
4-methylbenzamide
show the reaction diagram
4-methylmandelonitrile + H2O
4-methylmandelamine
show the reaction diagram
at 60% the rate of 2-hydroxy-4-phenylbutyronitrile
-
-
?
4-nitrobenzaldehyde + HCN + H2O
? + H2O
show the reaction diagram
-
-
100% conversion to alpha-hydroxy nitrile
-
?
5-cyanovaleric acid + H2O
6-amino-6-oxohexanoic acid
show the reaction diagram
-
NilFe and NilCo
-
-
r
5-hydroxymethyl-2-furonitrile + H2O
5-hydroxymethyl-2-furamide
show the reaction diagram
acetonitrile + H2O
acetamide
show the reaction diagram
acrylamide + H2O
acrylonitrile
show the reaction diagram
acrylonitrile + H2O
2-propenoic acid amide
show the reaction diagram
acrylonitrile + H2O
?
show the reaction diagram
acrylonitrile + H2O
acrylamide
show the reaction diagram
adiponitrile + H2O
5-cyanovaleramide
show the reaction diagram
adiponitrile + H2O
adipamide
show the reaction diagram
adiponitrile + H2O
adipic acid amide
show the reaction diagram
aeroplysinin-1 + H2O
verongiaquinol
show the reaction diagram
-
high substrate specificity towards the physiological substrate aeroplysinin-1
-
-
?
alpha-methylbenzyl cyanide + H2O
2-phenylpropanamide
show the reaction diagram
-
-
-
-
r
an aliphatic amide
a nitrile + H2O
show the reaction diagram
benzaldehyde + HCN
? + H2O
show the reaction diagram
-
-
95% conversion to alpha-hydroxy nitrile
-
?
benzeneacetonitrile + H2O
?
show the reaction diagram
very low activity
-
-
?
benzonitrile + H2O
?
show the reaction diagram
benzonitrile + H2O
benzamide
show the reaction diagram
benzonitrile + H2O
benzoic acid amide
show the reaction diagram
benzonitrile + hydroxylamine + H2O
benzohydroxamic acid + NH3
show the reaction diagram
benzylcyanide + H2O
2-phenylacetamide
show the reaction diagram
-
-
-
-
r
bromoxynil acid + H2O
?
show the reaction diagram
butyronitrile + H2O
?
show the reaction diagram
-
-
-
?
butyronitrile + H2O
butyramide
show the reaction diagram
butyronitrile + H2O
butyric acid amide
show the reaction diagram
-
best substrate
-
-
?
chloroacetonitrile + H2O
chloroacetamide
show the reaction diagram
chloroxynil acid + H2O
?
show the reaction diagram
chloroxynil amide + H2O
?
show the reaction diagram
crotononitrile + H2O
(E)-2-butenoic acid amide
show the reaction diagram
cyanamide + H2O
urea
show the reaction diagram
-
-
-
?
cyanide + H2O
formamide
show the reaction diagram
cyanopyrazine + H2O
pyrazincarbamide
show the reaction diagram
-
-
-
-
?
cyanovaleramide
valerodinitrile + H2O
show the reaction diagram
cyanovaleric acid + H2O
?
show the reaction diagram
cyclopropylcyanide + H2O
?
show the reaction diagram
-
-
-
-
?
dichlobenil acid + H2O
?
show the reaction diagram
-
-
-
-
?
dichlobenil amide + H2O
?
show the reaction diagram
ethyl 2-cyanobenzoate + H2O
ethyl 2-carbamoylbenzoate
show the reaction diagram
-
-
-
-
ir
ethyl 3-cyanobenzoate + H2O
ethyl 3-carbamoylbenzoate
show the reaction diagram
-
no conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
ethyl 4-cyanobenzoate + H2O
ethyl 4-carbamoylbenzoate
show the reaction diagram
ethylene cyanhydrine + H2O
?
show the reaction diagram
furan-2-carbonitrile + H2O
furan-2-carboxamide
show the reaction diagram
glutaronitrile + H2O
?
show the reaction diagram
-
38% of the activity with propionitrile
-
-
?
glycolonitrile + H2O
glycolamide
show the reaction diagram
-
yield 63%
-
?
hydroxyacetonitrile + H2O
hydroxyacetamide
show the reaction diagram
indole-3-acetonitrile + H2O
(indol-3-yl)acetamide
show the reaction diagram
indole-3-acetonitrile + H2O
(indole-3-yl)acetamide
show the reaction diagram
indole-3-acetonitrile + H2O
indole-3-acetamide
show the reaction diagram
indole-3-nitrile + H2O
indole-3-acetamide
show the reaction diagram
ioxynil acid + H2O
?
show the reaction diagram
isobutyronitrile + H2O
?
show the reaction diagram
-
-
-
?
isobutyronitrile + H2O
isobutyramide
show the reaction diagram
isobutyronitrile + H2O
isobutyric acid amide
show the reaction diagram
isovaleronitrile + H2O
isovaleric acid amide
show the reaction diagram
malonitrile + H2O
?
show the reaction diagram
-
44% of the activity with propionitrile
-
-
?
mandelonitrile + H2O
?
show the reaction diagram
methacrylamide + H2O
?
show the reaction diagram
methacrylonitrile + H2O
?
show the reaction diagram
-
-
-
-
?
methacrylonitrile + H2O
methacrylamide
show the reaction diagram
methacrylonitrile + H2O
methacrylic acid amide
show the reaction diagram
-
-
-
-
?
methacrylonitrile + H2O
methylacrylamide
show the reaction diagram
methacrylonitrile + H2O
methylacrylic acid amide
show the reaction diagram
methoxyacetonitrile + H2O
?
show the reaction diagram
-
-
-
-
?
methyl 4-cyanobenzoate + H2O
methyl 4-carbamoylbenzoate
show the reaction diagram
n-butyronitrile + H2O
n-butyramide
show the reaction diagram
-
-
-
-
r
n-butyronitrile + H2O
n-butyric acid amide
show the reaction diagram
n-capronitrile + H2O
n-hexanoic acid amide
show the reaction diagram
N-phenylglycinenitrile + H2O
?
show the reaction diagram
-
-
-
-
?
n-valeronitrile + H2O
n-valeramide
show the reaction diagram
naproxennitrile + H2O
?
show the reaction diagram
nicotinonitrile + H2O
nicotinamide
show the reaction diagram
o-chlorobenzonitrile + H2O
o-chlorobenzamide
show the reaction diagram
p-aminobenzonitrile + H2O
p-aminobenzamide
show the reaction diagram
-
conversion rate: 8.98%
-
-
?
p-chlorobenzonitrile + H2O
p-chlorobenzamide
show the reaction diagram
-
conversion rate: 93.1%
-
-
?
p-hydroxybenzylcyanide + H2O
2-(4-hydroxyphenyl)acetamide
show the reaction diagram
-
-
-
-
?
phenylacetonitrile + 2 H2O
phenylacetic acid + NH3
show the reaction diagram
-
-
-
?
phenylacetonitrile + H2O
2-phenylacetamide
show the reaction diagram
phenylacetonitrile + H2O
phenylacetamide
show the reaction diagram
phthalonitrile + H2O
2-cyanobenzamide
show the reaction diagram
-
lowest activity
-
-
?
phthalonitrile + H2O
?
show the reaction diagram
-
-
-
-
?
pivalonitrile + H2O
2,2-dimethylpropionic acid amide
show the reaction diagram
propionitrile + H2O
propionamide
show the reaction diagram
propionitrile + H2O
propionic acid amide
show the reaction diagram
pyridine-2-carbonitrile + H2O
pyridine-2-carboxamide
show the reaction diagram
pyridine-4-carbonitrile + H2O
pyridine-4-carboxamide
show the reaction diagram
succinonitrile + H2O
?
show the reaction diagram
-
135% of the activity with propionitrile
-
-
?
tert-butylisonitrile + H2O
?
show the reaction diagram
-
-
-
-
?
tert-butylisonitrile + H2O
tert-butyl amide
show the reaction diagram
thiophen-2-ylacetonitrile + H2O
2-(thiophen-2-yl)acetamide
show the reaction diagram
thiophene-2-carbonitrile + H2O
thiophen-2-carboxamide
show the reaction diagram
-
-
-
-
ir
thiophene-2-carbonitrile + H2O
thiophene-2-carboxamide
show the reaction diagram
-
99.9% conversion, in phosphate buffer pH 7.0, at 30C
-
-
?
toyocamycin + H2O
toyocamycin acid amide
show the reaction diagram
-
-
-
?
trans-4-cyanocyclohexane-1-carboxylic acid + H2O
4-(aminocarbonyl)cyclohexanecarboxylic acid
show the reaction diagram
trans-cinnamonitrile + H2O
trans-cinnamide
show the reaction diagram
-
-
-
-
?
valeronitrile + H2O
?
show the reaction diagram
-
-
-
?
valeronitrile + H2O
n-pentanoic acid amide
show the reaction diagram
valeronitrile + H2O
valeramide
show the reaction diagram
additional information
?
-