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Literature summary for 4.2.1.84 extracted from
- Full reaction mechanism of nitrile hydratase: a cyclic intermediate and an unexpected disulfide switch (2014), Inorg. Chem., 53, 2760-2762.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | an FeIII-NHase with a non-heme iron center. Structure of NHase active site showing the FeIII coordination sphere and some conserved residues, overview | Rhodococcus erythropolis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rhodococcus erythropolis | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| an aliphatic amide = a nitrile + H2O | detailed reaction mechanism using large quantum-mechanical active site models, overview. The attack of Cys114-SO- on the coordinated nitrile forms a cyclic intermediate. Cys109-S-S-Cys114 disulfide formation promotes cleavage of the latter to give the amide. Active-site regeneration occurs through attack of water on the disulfide, putative cyclic intermediate structure, overview | Rhodococcus erythropolis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NHase | - |
Rhodococcus erythropolis |
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Release 2023.1 (January 2023)
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