Reference on EC 3.4.24.80 - membrane-type matrix metalloproteinase-1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Buttner, F.H.; Hughes, C.E.; Margerie, D.; Lichte, A.; Tschesche, H.; Caterson, B.; Bartnik, E.
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan susbtrate rAgg1murt at the aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan
Biochem. J.
333
159-165
1998
Homo sapiens, Homo sapiens (P50281)
Fernandez-Catalan, C.; Bode, W.; Huber, R.; Turk, D.; Calvete, J.J.; Lichte, A.; Tchesche, H.; Maskos, K.
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor
EMBO J.
17
5238-5248
1998
Homo sapiens
Li, H.; Bauzon, D.E.; Xu, X.; Tschesche, H.; Cao, J.; Sang, Q.A.
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts
Mol. Carcinog.
22
84-94
1998
Homo sapiens
Annabi, B.; Lachambre, M.P.; Bousquet-Gagnon, N.; Page, M.; Gingras, D.; Beliveau, R.
Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains
Biochem. J.
353
547-553
2001
Homo sapiens (P50281)
Bini, A.; Wu, D.; Schnuer, J.; Kudryk, B.J.
Characterization of stromelysin 1 (MMP-3), matrilysin (MMP-7), and membrane type 1 matrix metalloproteinase (MT1-MMP) derived fibrin(ogen) fragments D-dimer and D-like monomer: NH2-terminal sequences of late-stage digest fragments
Biochemistry
38
13928-13936
1999
Homo sapiens (P50281)
Butler, G.; Butler, M.J.; Atkinson, S.J.; Will, H.; Tamura, T.; van Westrum Steven, S.; Crabbe, T.; Clements, J.; d'Ortho, M.P.; Murphy, G.
The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study
J. Biol. Chem.
273
871-880
1998
Homo sapiens (P50281)
Endo, K.; Takino, T.; Miyamori, H.; Kinsen, H.; Yoshizaki, T.; Furukawa, M.; Sato, H.
Cleavage of syndecan-1 by membrane-type matrix metalloproteinase-1 stimulates cell migration
J. Biol. Chem.
278
40764-40770
2003
Homo sapiens (P50281)
Galvez, B.G.; Matias-Roman, S.; Albar, J.P.; Sanchez-Madrid, F.; Arroyo, A.G.
Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling
J. Biol. Chem.
276
37491-37500
2001
Homo sapiens (P50281), Homo sapiens
Jiang, A.; Lehti, K.; Wang, X.; Weiss, S.J.; Keski-Oja, J.; Pei, D.
Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis
Proc. Natl. Acad. Sci. USA
98
13693-13698
2001
Homo sapiens (P50281)
Koo, H.M.; Kim, J.H.; Hwang, I.K.; Lee, S.J.; Kim, T.H.; Rhee, K.H.; Lee, S.T.
Refolding of the catalytic and hinge domains of human MT1-MMP expressed in Escherichia coli and its characterization
Mol. Cell
13
118-124
2002
Homo sapiens (P50281), Homo sapiens
Lohi, J.; Lehti, K.; Westermarck, J.; Kahari, V.M.; Keski-Oja, J.
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate
Eur. J. Biochem.
239
239-247
1996
Homo sapiens (P50281), Homo sapiens
Luo, X.H.; Liao, E.Y.
Progesterone differentially regulates the membrane-type matrix metalloproteinase-1 (MT1 -MMP) compartment of proMMP-2 activation in MG-63 cells
Horm. Metab. Res.
33
383-388
2001
Homo sapiens (P50281)
Pei, D.; Weiss, S.J.
Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity
J. Biol. Chem.
271
9135-9140
1996
Homo sapiens (P50281)
Roderfeld, M.; Buttner, F.H.; Bartnik, E.; Tschesche, H.
Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris
Protein Expr. Purif.
19
369-374
2000
Homo sapiens (P50281), Homo sapiens
Rozanov, D.V.; Deryugina, E.I.; Ratnikov, B.I.; Monosov, E.Z.; Marchenko, G.N.; Quigley, J.P.; Strongin, A.Y.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys574, the active site Glu240, and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells
J. Biol. Chem.
276
25705-25714
2001
Homo sapiens (P50281)
Rozanov, D.V.; Ghebrehiwet, B.; Postnova, T.I.; Eichinger, A.; Deryugina, E.I.; Strongin, A.Y.
The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR
J. Biol. Chem.
277
9318-9325
2002
Homo sapiens (P50281)
Sato, T.; Kondo, T.; Seiki, M.; Ito, A.
Cell type-specific involvement of furin in membrane type 1 matrix metalloproteinase-mediated progelatinase A activation
Ann. N. Y. Acad. Sci.
878
713-715
1999
Oryctolagus cuniculus, Homo sapiens (P50281)
Seiki, M.
Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion
Cancer Lett.
194
1-11
2003
Mus musculus, Homo sapiens (P50281), Homo sapiens
Shofuda, K.I.; Hasenstab, D.; Kenagy, R.D.; Shofuda, T.; Li, Z.Y.; Lieber, A.; Clowes, A.W.
Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells
FASEB J.
15
2010-2012
2001
Rattus norvegicus, Homo sapiens (P50281)
Toth, M.; Hernandez-Barrantes, S.; Osenkowski, P.; Bernardo, M.M.; Gervasi, D.C.; Shimura, Y.; Meroueh, O.; Kotra, L.P.; Galvez, B.G.; Arroyo, A.G.; Mobashery, S.; Fridman, R.
Complex pattern of membrane type 1 matrix metalloproteinase shedding: regulation by autocatalytic cell surface inactivation of active enzyme
J. Biol. Chem.
277
26340-26350
2002
Homo sapiens (P50281)
Uekita, T.; Itoh, Y.; Yana, I.; Ohno, H.; Seiki, M.
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity
J. Cell Biol.
155
1345-1356
2001
Homo sapiens (P50281)
Will, H.; Atkinson, S.J.; Butler, G.S.; Smith, B.; Murphy, G.
The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3
J. Biol. Chem.
271
17119-17123
1996
Homo sapiens (P50281)
Lee, M.H.; Rapti, M.; Murphy, G.
Unveiling the surface epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase
J. Biol. Chem.
278
40224-40230
2003
Homo sapiens
Rozanov, D.V.; Strongin, A.Y.
Membrane Type-1 Matrix metalloproteinase functions as a proprotein self-convertase
J. Biol. Chem.
278
8257-8260
2003
Homo sapiens (P50281)
Dong, Z.; Bonfil, R.D.; Chinni, S.; Deng, X.; Trindade Filho, J.C.; Bernardo, M.; Vaishampayan, U.; Che, M.; Sloane, B.F.; Sheng, S.; Fridman, R.; Cher, M.L.
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue
Am. J. Pathol.
166
1173-1186
2005
Homo sapiens
Hurst, D.R.; Schwartz, M.A.; Ghaffari, M.A.; Jin, Y.; Tschesche, H.; Fields, G.B.; Sang, Q.A.
Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities
Biochem. J.
377
775-779
2004
Homo sapiens
Toth, M.; Osenkowski, P.; Hesek, D.; Brown, S.; Meroueh, S.; Sakr, W.; Mobashery, S.; Fridman, R.
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase
Biochem. J.
387
497-506
2005
Homo sapiens
Hurst, D.R.; Schwartz, M.A.; Jin, Y.; Ghaffari, M.A.; Kozarekar, P.; Cao, J.; Sang, Q.X.
Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors
Biochem. J.
392
527-536
2005
Homo sapiens
Minond, D.; Lauer-Fields, J.L.; Nagase, H.; Fields, G.B.
Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability
Biochemistry
43
11474-11481
2004
Homo sapiens
Takino, T.; Miyamori, H.; Watanabe, Y.; Yoshioka, K.; Seiki, M.; Sato, H.
Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration
Cancer Res.
64
1044-1049
2004
Homo sapiens
Nisato, R.E.; Hosseini, G.; Sirrenberg, C.; Butler, G.S.; Crabbe, T.; Docherty, A.J.; Wiesner, M.; Murphy, G.; Overall, C.M.; Goodman, S.L.; Pepper, M.S.
Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical
Cancer Res.
65
9377-9387
2005
Bos taurus
Hasebe, T.; Hartman, R.; Matsuda, H.; Shi, Y.B.
Spatial and temporal expression profiles suggest the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis
Cell Tissue Res.
324
105-116
2006
Xenopus laevis (Q5USC3), Xenopus laevis
Deschamps, A.M.; Yarbrough, W.M.; Squires, C.E.; Allen, R.A.; McClister, D.M.; Dowdy, K.B.; McLean, J.E.; Mingoia, J.T.; Sample, J.A.; Mukherjee, R.; Spinale, F.G.
Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity
Circulation
111
1166-1174
2005
Sus scrofa
Rozanov, D.V.; Golubkov, V.S.; Strongin, A.Y.
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin
Int. J. Biochem. Cell Biol.
37
142-154
2005
Homo sapiens
Sounni, N.E.; Roghi, C.; Chabottaux, V.; Janssen, M.; Munaut, C.; Maquoi, E.; Galvez, B.G.; Gilles, C.; Frankenne, F.; Murphy, G.; Foidart, J.M.; Noel, A.
Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases
J. Biol. Chem.
279
13564-13574
2004
Homo sapiens
Cao, J.; Kozarekar, P.; Pavlaki, M.; Chiarelli, C.; Bahou, W.F.; Zucker, S.
Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration
J. Biol. Chem.
279
14129-14139
2004
Homo sapiens
Munshi, H.G.; Wu, Y.I.; Mukhopadhyay, S.; Ottaviano, A.J.; Sassano, A.; Koblinski, J.E.; Platanias, L.C.; Stack, M.S.
Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis
J. Biol. Chem.
279
39042-39050
2004
Homo sapiens
Tam, E.M.; Moore, T.R.; Butler, G.S.; Overall, C.M.
Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collage
J. Biol. Chem.
279
43336-43344
2004
Homo sapiens
Wu, Y.I.; Munshi, H.G.; Sen, R.; Snipas, S.J.; Salvesen, G.S.; Fridman, R.; Stack, M.S.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase
J. Biol. Chem.
279
8278-8289
2004
Homo sapiens (P50281), Homo sapiens
Savinov, A.Y.; Rozanov, D.V.; Golubkov, V.S.; Wong, F.S.; Strongin, A.Y.
Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas
J. Biol. Chem.
280
27755-27758
2005
Mus musculus
Mazzone, M.; Baldassarre, M.; Beznoussenko, G.; Giacchetti, G.; Cao, J.; Zucker, S.; Luini, A.; Buccione, R.
Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains
J. Cell Sci.
117
6275-6287
2004
Homo sapiens
Hwang, H.J.; Park, H.J.; Chung, H.J.; Min, H.Y.; Park, E.J.; Hong, J.Y.; Lee, S.K.
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells
J. Nutr. Biochem.
17
356-362
2006
Homo sapiens
Manase, K.; Endo, T.; Chida, M.; Nagasawa, K.; Honnma, H.; Yamazaki, K.; Kitajima, Y.; Goto, T.; Kanaya, M.; Hayashi, T.; Mitaka, T.; Saito, T.
Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
Reprod. Biol. Endocrinol.
4
32
2006
Rattus norvegicus
Bai, S.X.; Wang, Y.L.; Qin, L.; Xiao, Z.J.; Herva, R.; Piao, Y.S.
Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy
Reproduction
129
103-113
2005
Homo sapiens
Deschamps, A.M.; Zavadzkas, J.; Murphy, R.L.; Koval, C.N.; McLean, J.E.; Jeffords, L.; Saunders, S.M.; Sheats, N.J.; Stroud, R.E.; Spinale, F.G.
Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion
Am. J. Physiol. Heart Circ. Physiol.
294
H875-H883
2008
Sus scrofa
Atkinson, J.J.; Toennies, H.M.; Holmbeck, K.; Senior, R.M.
Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury
Am. J. Physiol. Lung Cell Mol. Physiol.
293
L600-L610
2007
Mus musculus
Wu, Y.I.; Munshi, H.G.; Snipas, S.J.; Salvesen, G.S.; Fridman, R.; Stack, M.S.
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking
Biochem. J.
407
171-177
2007
Homo sapiens
Lee, H.; Sodek, K.L.; Hwang, Q.; Brown, T.J.; Ringuette, M.; Sodek, J.
Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP
Biochem. Soc. Trans.
35
704-706
2007
Homo sapiens
Kudo, T.; Takino, T.; Miyamori, H.; Thompson, E.W.; Sato, H.
Substrate choice of membrane-type 1 matrix metalloproteinase is dictated by tissue inhibitor of metalloproteinase-2 levels
Cancer Sci.
98
563-568
2007
Homo sapiens
Arroyo, A.G.; Genis, L.; Gonzalo, P.; Matias-Roman, S.; Pollan, A.; Galvez, B.G.
Matrix metalloproteinases: new routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease
Curr. Pharm. Des.
13
1787-1802
2007
Homo sapiens
Alvarado, J.; del Castillo, J.R.; Thomas, L.E.
Modulation of membrane type 1 matrix metalloproteinase by LPS and gamma interferon bound to extracellular matrix in intestinal crypt cells
Cytokine
41
155-161
2008
Sus scrofa
Coyle, R.C.; Latimer, A.; Jessen, J.R.
Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: Evidence for an interaction with non-canonical Wnt signaling
Exp. Cell Res.
314
2150-2162
2008
Danio rerio
Itoh, Y.
MT1-MMP: a key regulator of cell migration in tissue
IUBMB Life
58
589-596
2006
Homo sapiens
Egawa, N.; Koshikawa, N.; Tomari, T.; Nabeshima, K.; Isobe, T.; Seiki, M.
Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells
J. Biol. Chem.
281
37576-37585
2006
Homo sapiens
Sithu, S.D.; English, W.R.; Olson, P.; Krubasik, D.; Baker, A.H.; Murphy, G.; D'Souza, S.E.
Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration
J. Biol. Chem.
282
25010-25019
2007
Homo sapiens
Basile, J.R.; Holmbeck, K.; Bugge, T.H.; Gutkind, J.S.
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D
J. Biol. Chem.
282
6899-6905
2007
Mus musculus
Currie, J.C.; Fortier, S.; Sina, A.; Galipeau, J.; Cao, J.; Annabi, B.
MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival
J. Biol. Chem.
282
8142-8149
2007
Homo sapiens
Cao, J.; Chiarelli, C.; Richman, O.; Zarrabi, K.; Kozarekar, P.; Zucker, S.
Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer
J. Biol. Chem.
283
6232-6240
2008
Homo sapiens
Gioia, M.; Monaco, S.; Fasciglione, G.F.; Coletti, A.; Modesti, A.; Marini, S.; Coletta, M.
Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains
J. Mol. Biol.
368
1101-1113
2007
Homo sapiens
Lee, H.; Overall, C.M.; McCulloch, C.A.; Sodek, J.
A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis
Mol. Biol. Cell
17
4812-4826
2006
Homo sapiens
Itoh, Y.; Ito, N.; Nagase, H.; Evans, R.D.; Bird, S.A.; Seiki, M.
Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP
Mol. Biol. Cell
17
5390-5399
2006
Homo sapiens
Langlois, S.; Nyalendo, C.; Di Tomasso, G.; Labrecque, L.; Roghi, C.; Murphy, G.; Gingras, D.; Beliveau, R.
Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation
Mol. Cancer Res.
5
569-583
2007
Homo sapiens
Ip, Y.C.; Cheung, S.T.; Fan, S.T.
Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma
Mol. Carcinog.
46
225-230
2007
Homo sapiens
Barbolina, M.V.; Stack, M.S.
Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis
Semin. Cell Dev. Biol.
19
24-33
2008
Homo sapiens
Zhang, W.; Matrisian, L.M.; Holmbeck, K.; Vick, C.C.; Rosenthal, E.L.
Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo
BMC Cancer
6
52
2006
Mus musculus
Barbolina, M.V.; Adley, B.P.; Ariztia, E.V.; Liu, Y.; Stack, M.S.
Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression
J. Biol. Chem.
282
4924-4931
2007
Homo sapiens
Schram, K.; Wong, M.M.; Palanivel, R.; No, E.K.; Dixon, I.M.; Sweeney, G.
Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts
J. Mol. Cell. Cardiol.
44
874-881
2008
Rattus norvegicus
Prinzen, C.; Truembach, D.; Wurst, W.; Endres, K.; Postina, R.; Fahrenholz, F.
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
BMC Genomics
10
66
2009
Homo sapiens
Devy, L.; Huang, L.; Naa, L.; Yanamandra, N.; Pieters, H.; Frans, N.; Chang, E.; Tao, Q.; Vanhove, M.; Lejeune, A.; van Gool, R.; Sexton, D.J.; Kuang, G.; Rank, D.; Hogan, S.; Pazmany, C.; Ma, Y.L.; Schoonbroodt, S.; Nixon, A.E.; Ladner, R.C.; Hoet, R.; Henderikx, P.; Tenhoor, C.; Rabbani, S.A.; Valentino, M.
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis
Cancer Res.
69
1517-1526
2009
Macaca fascicularis, Homo sapiens, Mus musculus, Rattus norvegicus
Park, J.H.; Park, S.M.; Park, S.H.; Cho, K.H.; Lee, S.T.
Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14
Proteomics
8
2926-2935
2008
Homo sapiens
Kolodziej, S.A.; Hockerman, S.L.; Boehm, T.L.; Carroll, J.N.; DeCrescenzo, G.A.; McDonald, J.J.; Mischke, D.A.; Munie, G.E.; Fletcher, T.R.; Rico, J.G.; Stehle, N.W.; Swearingen, C.; Becker, D.P.
Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective alpha-sulfone hydroxamates
Bioorg. Med. Chem. Lett.
20
3557-3560
2010
Rattus norvegicus
Sato, H.; Takino, T.
Coordinate action of membrane-type matrix metalloproteinase -1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion
Cancer Sci.
101
843-847
2010
Homo sapiens, Mus musculus
Feng, M.; Cai, X.J.; Zhang, W.; Liu, X.L.; Chen, L.; Zhang, Y.; Zhang, M.X.; Zhang, M.
Interleukin-6 enhances matrix metalloproteinase-14 expression via the RAF-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2-activator protein-1 pathway
Clin. Exp. Pharmacol. Physiol.
37
162-166
2010
Homo sapiens
Sounni, N.E.; Dehne, K.; van Kempen, L.; Egeblad, M.; Affara, N.I.; Cuevas, I.; Wiesen, J.; Junankar, S.; Korets, L.; Lee, J.; Shen, J.; Morrison, C.J.; Overall, C.M.; Krane, S.M.; Werb, Z.; Boudreau, N.; Coussens, L.M.
Stromal regulation of vessel stability by MMP14 and TGFbeta
Dis. Model. Mech.
3
317-332
2010
Homo sapiens, Mus musculus
Laudanski, P.; Swiatecka, J.; Kozlowski, L.; Lesniewska, M.; Wojtukiewicz, M.; Wolczynski, S.
Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer
Folia Histochem. Cytobiol.
48
101-103
2010
Homo sapiens
Niiya, D.; Egawa, N.; Sakamoto, T.; Kikkawa, Y.; Shinkawa, T.; Isobe, T.; Koshikawa, N.; Seiki, M.
Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells
J. Biol. Chem.
284
27360-27369
2009
Homo sapiens
Gawden-Bone, C.; Zhou, Z.; King, E.; Prescott, A.; Watts, C.; Lucocq, J.
Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14
J. Cell Sci.
123
1427-1437
2010
Mus musculus
Liu, G.; Atteridge, C.L.; Wang, X.; Lundgren, A.D.; Wu, J.D.
The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases
J. Immunol.
184
3346-3350
2010
Homo sapiens, Mus musculus
Kaner, R.J.; Santiago, F.; Crystal, R.G.
Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema
J. Leukoc. Biol.
86
913-922
2009
Homo sapiens
Chiu, H.C.; Lu, Y.T.; Chin, Y.T.; Tu, H.P.; Chiang, C.Y.; Gau, C.H.; Nieh, S.; Fu, E.
Cyclosporine A inhibits the expression of membrane type-I matrix metalloproteinase in gingiva
J. Periodontal Res.
44
338-347
2009
Homo sapiens, Rattus norvegicus
Cuadrado, E.; Rosell, A.; Penalba, A.; Slevin, M.; Alvarez-Sabin, J.; Ortega-Aznar, A.; Montaner, J.
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
J. Proteome Res.
8
3191-3197
2009
Homo sapiens
Crispi, S.; Calogero, R.A.; Santini, M.; Mellone, P.; Vincenzi, B.; Citro, G.; Vicidomini, G.; Fasano, S.; Meccariello, R.; Cobellis, G.; Menegozzo, S.; Pierantoni, R.; Facciolo, F.; Baldi, A.; Menegozzo, M.
Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target
PLoS ONE
4
e7016
2009
Homo sapiens
Itoh, Y.; Takamura, A.; Ito, N.; Maru, Y.; Sato, H.; Suenaga, N.; Aoki, T.; Seiki, M.
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
EMBO J.
20
4782-4793
2001
Homo sapiens
Gioia, M.; Fasciglione, G.F.; Monaco, S.; Iundusi, R.; Sbardella, D.; Marini, S.; Tarantino, U.; Coletta, M.
pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain
J. Biol. Inorg. Chem.
15
1219-1232
2010
Homo sapiens
Hawinkels, L.J.; Kuiper, P.; Wiercinska, E.; Verspaget, H.W.; Liu, Z.; Pardali, E.; Sier, C.F.; ten Dijke, P.
Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis
Cancer Res.
70
4141-4150
2010
Homo sapiens
Koshikawa, N.; Mizushima, H.; Minegishi, T.; Iwamoto, R.; Mekada, E.; Seiki, M.
Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor
Cancer Res.
70
6093-6103
2010
Homo sapiens, Mus musculus
Koshikawa, N.; Mizushima, H.; Minegishi, T.; Eguchi, F.; Yotsumoto, F.; Nabeshima, K.; Miyamoto, S.; Mekada, E.; Seiki, M.
Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells
Cancer Sci.
102
111-116
2011
Homo sapiens
Shields, M.A.; Dangi-Garimella, S.; Krantz, S.B.; Bentrem, D.J.; Munshi, H.G.
Pancreatic cancer cells respond to type I collagen by inducing Snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion
J. Biol. Chem.
286
10495-10504
2011
Homo sapiens
Eisenach, P.A.; Correa de Sampaio, P.; Murphy, G.; Roghi, C.
Membrane-type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at K581 increases cellular invasion through type-I collagen
J. Biol. Chem.
287
11533-11545
2012
Homo sapiens
Nguyen, H.L.; Zucker, S.; Zarrabi, K.; Kadam, P.; Schmidt, C.; Cao, J.
Oxidative stress and prostate cancer progression are elicited by membrane-type 1 matrix metalloproteinase
Mol. Cancer Res.
9
1305-1318
2011
Homo sapiens
Cork, S.M.; Kaur, B.; Devi, N.S.; Cooper, L.; Saltz, J.H.; Sandberg, E.M.; Kaluz, S.; Van Meir, E.G.
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1
Oncogene
31
5144-5152
2012
Homo sapiens
Ogata, H.; Decaneto, E.; Grossman, M.; Havenith, M.; Sagi, I.; Lubitz, W.; Knipp, M.
Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase
Acta Crystallogr. Sect. F
70
232-235
2014
Homo sapiens (P50281)
Yang, C.; Zhu, L.; Xu, X.; Ning, T.; Ye, J.; Liu, L.
Membrane type 1 matrix metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells
BMC Cancer
13
171
2013
Homo sapiens (P50281), Homo sapiens
Domoto, T.; Takino, T.; Guo, L.; Sato, H.
Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase
Cancer Sci.
103
448-454
2012
Homo sapiens (P50281)
Guo, L.; Takino, T.; Endo, Y.; Domoto, T.; Sato, H.
Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase
J. Biochem.
152
425-432
2012
Homo sapiens (P50281)
Woskowicz, A.M.; Weaver, S.A.; Shitomi, Y.; Ito, N.; Itoh, Y.
MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion
J. Biol. Chem.
288
35126-35137
2013
Homo sapiens (P50281)
Birukawa, N.; Murase, K.; Sato, Y.; Kosaka, A.; Yoneda, A.; Nishita, H.; Fujita, R.; Nishimura, M.; Ninomiya, T.; Kajiwara, K.; Miyazaki, M.; Nakashima, Y.; Ota, S.; Murakami, Y.; Tanaka, Y.; Minomi, K.; Tamura, Y.; Niitsu, Y.
Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth
J. Biol. Chem.
289
20209-20221
2014
Homo sapiens (P50281)
Ma, J.; Tang, X.; Wong, P.; Jacobs, B.; Borden, E.C.; Bedogni, B.
Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation
J. Biol. Chem.
289
8442-8449
2014
Homo sapiens (P50281)
Nishihara, T.; Remacle, A.; Angert, M.; Shubayev, I.; Shiryaev, S.; Liu, H.; Dolkas, J.; Chernov, A.; Strongin, A.; Shubayev, V.
Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury
J. Biol. Chem.
290
3693-3707
2015
Rattus norvegicus (Q10739)
Tassone, E.; Valacca, C.; Mignatti, P.
Membrane-type 1 matrix metalloproteinase downregulates fibroblast growth factor-2 binding to the cell surface and intracellular signaling
J. Cell. Physiol.
230
366-377
2015
Homo sapiens (P50281)
Sathyamoorthy, T.; Tezera, L.B.; Walker, N.F.; Brilha, S.; Saraiva, L.; Mauri, F.A.; Wilkinson, R.J.; Friedland, J.S.; Elkington, P.T.
Membrane type 1 matrix metalloproteinase regulates monocyte migration and collagen destruction in tuberculosis
J. Immunol.
195
882-889
2015
Homo sapiens (P50281), Homo sapiens
Gaublomme, D.; Buyens, T.; De Groef, L.; Stakenborg, M.; Janssens, E.; Ingvarsen, S.; Porse, A.; Behrendt, N.; Moons, L.
Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells
J. Neurochem.
129
966-979
2014
Mus musculus (P53690)
Assent, D.; Bourgot, I.; Hennuy, B.; Geurts, P.; Nol, A.; Foidart, J.; Maquoi, E.
A Membrane-type-1 matrix metalloproteinase (MT1-MMP) - discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells
PLoS ONE
10
e116006
2015
Homo sapiens (P50281), Homo sapiens
Li, X.; Ma, Z.; Wang, H.; Ren, L.; Zhang, D.; Liang, W.; Zhang, G.; Zhang, J.; Yu, D.; Fang, X.
Screening, identification, and characterization of an affinity peptide specific to MT1-MMP and its application in tumor imaging
Bioconjug. Chem.
30
1507-1517
2019
Homo sapiens (P50281)
Cuffaro, D.; Nuti, E.; Gifford, V.; Ito, N.; Camodeca, C.; Tuccinardi, T.; Nencetti, S.; Orlandini, E.; Itoh, Y.; Rossello, A.
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)
Bioorg. Med. Chem.
27
196-207
2019
Homo sapiens (P50281)
Decaneto, E.; Suladze, S.; Rosin, C.; Havenith, M.; Lubitz, W.; Winter, R.
Pressure and temperature effects on the activity and structure of the catalytic domain of human MT1-MMP
Biophys. J.
109
2371-2381
2015
Homo sapiens (P50281), Homo sapiens
Pahwa, S.; Bhowmick, M.; Amar, S.; Cao, J.; Strongin, A.Y.; Fridman, R.; Weiss, S.J.; Fields, G.B.
Characterization and regulation of MT1-MMP cell surface-associated activity
Chem. Biol. Drug Des.
93
1251-1264
2019
Homo sapiens (P50281)
Feinberg, T.Y.; Rowe, R.G.; Saunders, T.L.; Weiss, S.J.
Functional roles of MMP14 and MMP15 in early postnatal mammary gland development
Development
143
3956-3968
2016
Mus musculus (P53690)
de Vos, I.J.; Tao, E.Y.; Ming Ong, S.L.; Goggi, J.L.; Scerri, T.; Wilson, G.R.; Low, C.G.M.; Wong, A.S.W.; Grussu, D.; Stegmann, A.P.A.; van Geel, M.; Janssen, R.; Amor, D.J.; Bahlo, M.; Dunn, N.R.; Carney, T.J.; Lockhart, P.J.; Coull, B.J.; van Steensel, M.A.M.
Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype
Hum. Mol. Genet.
27
2775-2788
2018
Homo sapiens (P50281), Homo sapiens, Danio rerio (Q7T2J1), Danio rerio (Q7T2J2), Danio rerio
Majali-Martinez, A.; Velicky, P.; Pollheimer, J.; Knoefler, M.; Yung, H.W.; Burton, G.J.; Tabrizi-Wizsy, N.G.; Lang, U.; Hiden, U.; Desoye, G.; Dieber-Rotheneder, M.
Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B
Hum. Reprod.
32
46-54
2017
Homo sapiens (P50281), Homo sapiens
Fan, L.; Liu, L.; Zhu, C.; Zhu, Q.; Lu, S.; Liu, P.
MT1-MMP inhibits the activity of Bst-2 via their cytoplasmic domains dependent interaction
Int. J. Mol. Sci.
17
818
2016
no activity in Canis familiaris, Homo sapiens (P50281)
Overland, A.C.; Insel, P.A.
Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease. A novel mechanism for GPCR-EGFR transactivation
J. Biol. Chem.
290
9941-9947
2015
Mus musculus (P53690), Rattus norvegicus (Q10739), Rattus norvegicus Sprague-Dawley (Q10739)
Majkowska, I.; Shitomi, Y.; Ito, N.; Gray, N.S.; Itoh, Y.
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts
J. Biol. Chem.
292
6633-6643
2017
Homo sapiens (P50281), Homo sapiens
Sakr, M.; Li, X.-Y.; Sabeh, F.; Feinberg, T.Y.; Tesmer, J.J.G.; Tang, Y.; Weiss, S.J.
Tracking the Cartoon mouse phenotype hemopexin domain-dependent regulation of MT1-MMP pericellular collagenolytic activity
J. Biol. Chem.
293
8113-8127
2018
Mus musculus (P53690)
Ikonomidis, J.S.; Nadeau, E.K.; Akerman, A.W.; Stroud, R.E
; Mukherjee, R.; Jones, J.A. Regulation of membrane type-1 matrix metalloproteinase activity and intracellular localization in clinical thoracic aortic aneurysms
J. Thorac. Cardiovasc. Surg.
153
537-546
2017
Mus musculus (P53690), Mus musculus
Butler, G.S.; Connor, A.R.; Sounni, N. E.; Eckhard, U.; Morrison, C.J.; Noel, A.; Overall, C.M.
Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates CCN3 (Nov) and CCN5 (WISP2)
Matrix Biol.
59
23-38
2017
Homo sapiens (P50281)
Decaneto, E.; Vasilevskaya, T.; Kutin, Y.; Ogata, H.; Grossman, M.; Sagi, I.; Havenith, M.; Lubitz, W.; Thiel, W.; Cox, N.
Solvent water interactions within the active site of the membrane type I matrix metalloproteinase
Phys. Chem. Chem. Phys.
19
30316-30331
2017
Homo sapiens (P50281)
Cerofolini, L.; Amar, S.; Lauer, J.L.; Martelli, T.; Fragai, M.; Luchinat, C.; Fields, G.B.
Bilayer membrane modulation of membrane type 1 matrix metalloproteinase (MT1-MMP) structure and proteolytic activity
Sci. Rep.
6
29511
2016
Homo sapiens (P50281)
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