Any feedback?
Literature summary for 3.4.24.80 extracted from
- Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression (2007), J. Biol. Chem., 282, 4924-4931.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | beta1 integrin clustering enhances MT1-MMP expression | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | transcription factor EGR1 gene silencing by siRNA blocks collagen-induced MT1-MMP expression and collagen invasion, integrin signaling through a SRC kinase-dependent pathway is necessary for EGR1 induction, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | Homo sapiens | degradation | ? | - |
? |  |
| additional information | Homo sapiens | enzyme regulation, transcription factor EGR1 is involved, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| DOV-13 cell | - |
Homo sapiens | - |
| ovarian carcinoma cell | cells from different carcinoma types, expression analysis, overview | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
quantitative MT1-MMP expression analysis by RT-PCR, cellular invasion assay, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen I + H2O | degradation | Homo sapiens | ? | - |
? | |
| collagen I + H2O | degradation, substrate from rat tail | Homo sapiens | ? | - |
? | |
| additional information | enzyme regulation, transcription factor EGR1 is involved, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane type 1 matrix metalloproteinase | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
