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Literature summary for 3.4.24.80 extracted from
- Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor (2010), Cancer Res., 70, 6093-6103.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
x * 70000, SDS-PAGE | Mus musculus |
| 70000 | - |
x * 70000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | - |
Mus musculus | - |
| MKN-28 cell | - |
Homo sapiens | - |
| MKN-7 cell | - |
Homo sapiens | - |
| STKM-2 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heparin-binding epidermal growth factor + H2O | the enzyme removes the NH2-terminal 20 amino acids by cleaving between A-83LC | Mus musculus | ? | - |
? |  |
| heparin-binding epidermal growth factor + H2O | the enzyme removes the NH2-terminal 20 amino acids by cleaving between A-83LC | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 70000, SDS-PAGE | Mus musculus |
| ? | x * 70000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane type 1-matrix metalloproteinase | - |
Mus musculus |
| membrane type 1-matrix metalloproteinase | - |
Homo sapiens |
| MMP14 | - |
Mus musculus |
| MMP14 | - |
Homo sapiens |
| MT1-MMP | - |
Mus musculus |
| MT1-MMP | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the processing of heparin-binding epidermal growth factor by MT1-MMP converts the substrate into a heparin-independent growth factor with enhanced mitogenic activity, and thereby, expression of both proteins costimulates tumor cell growth in vitro and in vivo | Mus musculus |
| physiological function | the processing of heparin-binding epidermal growth factor by MT1-MMP converts the substrate into a heparin-independent growth factor with enhanced mitogenic activity, and thereby, expression of both proteins costimulates tumor cell growth in vitro and in vivo | Homo sapiens |
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