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Literature summary for 3.4.24.80 extracted from

  • Park, J.H.; Park, S.M.; Park, S.H.; Cho, K.H.; Lee, S.T.
    Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14 (2008), Proteomics, 8, 2926-2935.
    View publication on PubMed
Search for more literature for 3.4.24.80

Application

Application Comment Organism
medicine considering the important role of apolipoproteinE for lipid metabolism and atherosclerosis protection, MMP-14 might play an essential role for the development of hyperlipidemia and atherosclerosis as a result of degradation of apolipoprotein E Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GM6001 pan-metalloprotease inhibitor inhibits degradation of apolipoprotein E Homo sapiens
TIMP-2 inhibits degradation of apolipoprotein E Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apolipoprotein E + H2O the 34 kDa apoE protein is initially processed by MMP-14 into fragments with molecular masses of 28, 23, 21, and 11 kDa. The primary MMP-14 cleavage sites are Ala176-Ile177, Pro183-Leu184, Pro202-Leu203, and Gln249-Ile250. The MMP-14-mediated cleavage of apoE is consistent regardless of whether apoE exists in its lipid-bound or lipid-free form. Upon digestion with MMP-14, apoE loses its ability to suppress the platelet-derived growth factor-induced migration of rat vascular smooth muscle cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-14
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens