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Literature summary for 3.4.24.80 extracted from

  • Sathyamoorthy, T.; Tezera, L.B.; Walker, N.F.; Brilha, S.; Saraiva, L.; Mauri, F.A.; Wilkinson, R.J.; Friedland, J.S.; Elkington, P.T.
    Membrane type 1 matrix metalloproteinase regulates monocyte migration and collagen destruction in tuberculosis (2015), J. Immunol., 195, 882-889.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
 x * 54000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
-
-

Source Tissue

Source Tissue Comment Organism Textmining
infectious granuloma cell
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-
sputum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 54000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
membrane type 1 matrix metalloproteinase
-
 Homo sapiens
MMP-14
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in patients with tuberculosis, induced sputum enzyme mRNA levels are increased 5.1fold compared with matched controls. Mycobacterium tuberculosis infection of primary human monocytes increases enzyme surface expression 31.7fold and gene expression 24.5fold up

General Information

General Information Comment Organism
physiological function the enzyme is critical to monocyte migration Homo sapiens