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Literature summary for 3.4.24.80 extracted from

  • Zhang, W.; Matrisian, L.M.; Holmbeck, K.; Vick, C.C.; Rosenthal, E.L.
    Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo (2006), BMC Cancer, 6, 52.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Cloned(Commentary)

Cloned (Comment) Organism
MT1-MMP expression in both the epithelial and stromal elements of head and neck squamous cell carcinoma cell line, low enzyme activity Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient fibroblasts show impaired invasion of type I collagen matrices, MT1-MMP null fibroblasts fail to penetrate the matrix Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
tissue inhibitor of matrix metalloproteinase-1 i.e. TIMP-1, recombinant, human Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Mus musculus degradation ?
-
 ?
additional information Mus musculus in vivo growth of FaDu cells co-injected with murine fibroblasts is increased, while their progression is reduced in MT1-MMP-deficient fibroblasts, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Black Swiss mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification furin processes MT1-MMP to its active form, inhibited by synthetic peptidyl chloromethyl ketones Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast isolated from the dermis of late gestation embryos in mice deficient in MT1-MMP Mus musculus
-
additional information no enzyme activity in serum of healthy mice Mus musculus
-
salivary duct cancer cell expression in in both the epithelial and stromal elements, low enzyme activity Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O degradation Mus musculus ?
-
 ?
additional information in vivo growth of FaDu cells co-injected with murine fibroblasts is increased, while their progression is reduced in MT1-MMP-deficient fibroblasts, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MT1-MMP
-
 Mus musculus