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Literature summary for 3.4.24.80 extracted from

  • Endo, K.; Takino, T.; Miyamori, H.; Kinsen, H.; Yoshizaki, T.; Furukawa, M.; Sato, H.
    Cleavage of syndecan-1 by membrane-type matrix metalloproteinase-1 stimulates cell migration (2003), J. Biol. Chem., 278, 40764-40770.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutant defective in catalytic domain, deletion of transmembrane/cytoplasmic domain, deletion of hemopexin domain abolishes enzyme activity, whereas substitution of transmembrane/cytoplasmic membrane with Il-2 receptor does not affect it Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in cell migration ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in cell migration Homo sapiens ?
-
?
syndecan-1 core protein + H2O cleaves preferably at G245-L246 peptide bond Homo sapiens ?
-
?
syndecan-1 G245L glutathione transferase protein + H2O cleaves at G82-L83 peptide bond Homo sapiens ?
-
?