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Literature summary for 3.4.24.80 extracted from

  • Liu, G.; Atteridge, C.L.; Wang, X.; Lundgren, A.D.; Wu, J.D.
    The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases (2010), J. Immunol., 184, 3346-3350.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Protein Variants

Protein Variants Comment Organism
additional information suppression of MMP14 expression in human MCF-7 breast cells blocks MHC class I chain-related molecule A, MICA, shedding, while overexpression of MMP14 enhances it, overview Homo sapiens
additional information suppression of MMP14 expression in mouse MyC-CaP prostate cancer cells blocks MHC class I chain-related molecule A, MICA, shedding, while overexpression of MMP14 enhances it, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
pervanadate a tyrosine phosphatase inhibitor, regulates the activity of MT-MMPs, and accelerates MMP14-mediated shedding of several membrane-anchored proteins Mus musculus
pervanadate a tyrosine phosphatase inhibitor, regulates the activity of MT-MMPs, and accelerates MMP14-mediated shedding of several membrane-anchored proteins Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
M12 prostate cancer cell prostate tumor cell line Homo sapiens
-
MCF-7 cell breast tumor cell line Homo sapiens
-
Myc-CaP cell prostate tumor cell line Mus musculus
-
PC-3 cell prostate tumor cell line Homo sapiens
-
TRAMP-C2 cell prostate tumor cell line Mus musculus
-

Synonyms

Synonyms Comment Organism
membrane type matrix metalloproteinase
-
 Mus musculus
membrane type matrix metalloproteinase
-
 Homo sapiens
MMP14
-
 Mus musculus
MMP14
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction MMP14 mediates tumor cell surface MHC class I chain-related molecule A shedding, suppression of MMP14 expression blocks MICA shedding, while overexpression of MMP14 enhances it. The regulation is independent of the activity of a disintegrin and metalloproteinases, overview Mus musculus
malfunction MMP14 mediates tumor cell surface MHC class I chain-related molecule A shedding, suppression of MMP14 expression blocks MICA shedding, while overexpression of MMP14 enhances it. The regulation is independent of the activity of a disintegrin and metalloproteinases, overview Homo sapiens