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Literature summary for 3.4.24.80 extracted from

  • Takino, T.; Miyamori, H.; Watanabe, Y.; Yoshioka, K.; Seiki, M.; Sato, H.
    Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration (2004), Cancer Res., 64, 1044-1049.
    View publication on PubMed
Search for more literature for 3.4.24.80

Application

Application Comment Organism
medicine MT1-MMP is involved in cell migration and collagen-induced mitogen-activated protein kinase-extracellular signal-related kinase activation, collagen-induced mitogen-activated protein kinase-extracellular signal-related kinase activation inhances MT1-MMP activity, hemopexin-like domain of MT1-MMP inhibits collagen-induced mitogen-activated protein kinase-extracellular signal-related kinase activation and migration Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information catalytic inactive mutant (E/A) of MT1-MMP Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BB94 supresses migration of HT1080 cells on type I collagen to 69% Homo sapiens
additional information migration of HT1080 cells on type I collagen not supressed by TIMP-1 Homo sapiens
PD98059 inhibits MMP-2 processing in HT1080 cells Homo sapiens
TIMP-2 supresses migration of HT1080 cells on type I collagen to 62% Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
membrane type 1 matrix metalloproteinase
-
 Homo sapiens
membrane type 1 MMP
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens