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Literature summary for 3.4.24.80 extracted from

  • Toth, M.; Hernandez-Barrantes, S.; Osenkowski, P.; Bernardo, M.M.; Gervasi, D.C.; Shimura, Y.; Meroueh, O.; Kotra, L.P.; Galvez, B.G.; Arroyo, A.G.; Mobashery, S.; Fridman, R.
    Complex pattern of membrane type 1 matrix metalloproteinase shedding: regulation by autocatalytic cell surface inactivation of active enzyme (2002), J. Biol. Chem., 277, 26340-26350.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
18 kDa inactive fragment ranging from Tyr 112 to Ala 255, 21 kDa fragment ranging from Tyr 122 to Gly 284 and truncated form lacking the cytosolic domain Homo sapiens

Protein Variants

Protein Variants Comment Organism
E240A catalytically inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
marimastat inhibits production of 18 kDa fragment during autocatalytic processing Homo sapiens
TIMP-2 inhibits production of 18 kDa fragment during autocatalytic processing Homo sapiens
TIMP-4 inhibits production of 18 kDa fragment during autocatalytic processing Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
MOCAcPLGLA2pr-dinitrophenol-A-RNH2 pH 7.5, Tyr112-Gly284 fragment Homo sapiens
0.01
-
MOCAcPLGLA2pr-dinitrophenol-A-RNH2 pH 7.5, Tyr112-Gly288 fragment Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
570000
-
active form, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
-
-

Purification (Commentary)

Purification (Comment) Organism
18 kDa and 21 kDa fragment, homogeneity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MOCAcPLGLA2pr-dinitrophenol-A-RNH2 + H2O fluorogenic substrate Homo sapiens ?
-
?
progelatinase A + H2O 21 kDa fragment Homo sapiens ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.02
-
MOCAcPLGLA2pr-dinitrophenol-A-RNH2 pH 7.5, Tyr112-Gly288 fragment Homo sapiens
0.055
-
MOCAcPLGLA2pr-dinitrophenol-A-RNH2 pH 7.5, Tyr112-Gly284 fragment Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000005
-
TIMP-2 Tyr112-Gly288 fragment Homo sapiens
0.00000006
-
TIMP-2 Tyr112-Gly288 fragment Homo sapiens